Chronic Gastritis in Dermatitis Herpetiformis: A Controlled Study
Background and Objective. Previous small studies suggest that chronic atrophic gastritis is common in dermatitis herpetiformis (DH). We here examined the frequency and topography of chronic gastritis in 93 untreated DH subjects and in 186 controls with dyspepsia. Methods. Specimens were drawn from t...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/640630 |
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| author | Anna Alakoski Teea T. Salmi Kaisa Hervonen Hannu Kautiainen Maarit Salo Katri Kaukinen Timo Reunala Pekka Collin |
| author_facet | Anna Alakoski Teea T. Salmi Kaisa Hervonen Hannu Kautiainen Maarit Salo Katri Kaukinen Timo Reunala Pekka Collin |
| author_sort | Anna Alakoski |
| collection | DOAJ |
| description | Background and Objective. Previous small studies suggest that chronic atrophic gastritis is common in dermatitis herpetiformis (DH). We here examined the frequency and topography of chronic gastritis in 93 untreated DH subjects and in 186 controls with dyspepsia. Methods. Specimens were drawn from the gastric corpus and antrum and examined for atrophy, intestinal metaplasia, and Helicobacter pylori. Duodenal biopsies were taken. Results. Atrophic corpus gastritis was more frequent in DH than in controls (16.0% and 2.7%, resp., P<0.001); atrophy in the antrum was rare in both groups (3.2% and 1.1%, P=0.34). Intestinal metaplasia was present in 13 (14.0%) DH and 12 (6.5%) control patients (P=0.038) and H. pylori in 17 (18.3%) and 17 (9.3%) (P=0.028), respectively. Small-bowel villous atrophy was seen in 76% of the DH patients, equally in patients with and without chronic gastritis. One DH patient with atrophic gastritis developed gastric cancer. Conclusion. In DH, chronic atrophic gastritis was common in the corpus, but not in the antrum. H. pylori will partly explain this, but corpus atrophy is suggestive of an autoimmune etiology. Atrophic gastritis may increase the risk of gastric cancer. We advocate performing upper endoscopy with sufficient histologic samples in DH. |
| format | Article |
| id | doaj-art-ee376b7e0b4f438d80374b8e349da5dc |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-ee376b7e0b4f438d80374b8e349da5dc2025-02-03T06:05:21ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/640630640630Chronic Gastritis in Dermatitis Herpetiformis: A Controlled StudyAnna Alakoski0Teea T. Salmi1Kaisa Hervonen2Hannu Kautiainen3Maarit Salo4Katri Kaukinen5Timo Reunala6Pekka Collin7Department of Dermatology, Tampere University Hospital, 33521 Tampere, FinlandDepartment of Dermatology, Tampere University Hospital, 33521 Tampere, FinlandDepartment of Dermatology, Tampere University Hospital, 33521 Tampere, FinlandUnit of Family Practice, Central Finland Central Hospital, and Unit of Primary Health Care, Kuopio University Hospital, 70211 Kuopio, FinlandValkeakoski Regional Hospital, Department of Medicine, 37600 Valkeakoski, FinlandSchool of Medicine, University of Tampere, 33014 Tampere, FinlandDepartment of Dermatology, Tampere University Hospital, 33521 Tampere, FinlandSchool of Medicine, University of Tampere, 33014 Tampere, FinlandBackground and Objective. Previous small studies suggest that chronic atrophic gastritis is common in dermatitis herpetiformis (DH). We here examined the frequency and topography of chronic gastritis in 93 untreated DH subjects and in 186 controls with dyspepsia. Methods. Specimens were drawn from the gastric corpus and antrum and examined for atrophy, intestinal metaplasia, and Helicobacter pylori. Duodenal biopsies were taken. Results. Atrophic corpus gastritis was more frequent in DH than in controls (16.0% and 2.7%, resp., P<0.001); atrophy in the antrum was rare in both groups (3.2% and 1.1%, P=0.34). Intestinal metaplasia was present in 13 (14.0%) DH and 12 (6.5%) control patients (P=0.038) and H. pylori in 17 (18.3%) and 17 (9.3%) (P=0.028), respectively. Small-bowel villous atrophy was seen in 76% of the DH patients, equally in patients with and without chronic gastritis. One DH patient with atrophic gastritis developed gastric cancer. Conclusion. In DH, chronic atrophic gastritis was common in the corpus, but not in the antrum. H. pylori will partly explain this, but corpus atrophy is suggestive of an autoimmune etiology. Atrophic gastritis may increase the risk of gastric cancer. We advocate performing upper endoscopy with sufficient histologic samples in DH.http://dx.doi.org/10.1155/2012/640630 |
| spellingShingle | Anna Alakoski Teea T. Salmi Kaisa Hervonen Hannu Kautiainen Maarit Salo Katri Kaukinen Timo Reunala Pekka Collin Chronic Gastritis in Dermatitis Herpetiformis: A Controlled Study Clinical and Developmental Immunology |
| title | Chronic Gastritis in Dermatitis Herpetiformis: A Controlled Study |
| title_full | Chronic Gastritis in Dermatitis Herpetiformis: A Controlled Study |
| title_fullStr | Chronic Gastritis in Dermatitis Herpetiformis: A Controlled Study |
| title_full_unstemmed | Chronic Gastritis in Dermatitis Herpetiformis: A Controlled Study |
| title_short | Chronic Gastritis in Dermatitis Herpetiformis: A Controlled Study |
| title_sort | chronic gastritis in dermatitis herpetiformis a controlled study |
| url | http://dx.doi.org/10.1155/2012/640630 |
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