Diagnostic and prognostic performance of serum GPC3 and PIVKA-II in AFP-negative hepatocellular carcinoma and establishment of nomogram prediction models

Diagnostic and prognostic performance of serum GPC3 and PIVKA-II in AFP-negative hepatocellular carcinoma and establishment of nomogram prediction models

Abstract Objective A significant proportion, ranging from 20 to 40%, of individuals with hepatocellular carcinoma (HCC) do not exhibit elevated Alpha-fetoprotein (AFP) levels. This study aimed to evaluate the utility of serum glypican-3 (GPC3) and protein induced by vitamin K absence or antagonist I...

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Bibliographic Details
Main Authors: Yingying Lin, Yuefei Ma, Yan Chen, Yepei Huang, Jinchuan Lin, Zhenzhou Xiao, Zhaolei Cui
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Cancer
Subjects:
Glypican-3
Protein induced by vitamin K absence or antagonist II
Hepatocellular carcinoma
Diagnosis
Prognosis
Nomogram
Online Access:https://doi.org/10.1186/s12885-025-14025-y
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