Thrombospondin-1: Multiple Paths to Inflammation
Inflammation is a defensive process against tissue injury. Once this self-protective strategy is initiated, an effective resolution of the process is crucial to avoid major and unnecessary tissue damage. If the underlying event inducing inflammation is not addressed and homeostasis is not restored,...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2011/296069 |
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| _version_ | 1832549830070632448 |
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| author | Zenaida Lopez-Dee Kenneth Pidcock Linda S. Gutierrez |
| author_facet | Zenaida Lopez-Dee Kenneth Pidcock Linda S. Gutierrez |
| author_sort | Zenaida Lopez-Dee |
| collection | DOAJ |
| description | Inflammation is a defensive process against tissue injury. Once this self-protective strategy is initiated, an effective resolution of the process is crucial to avoid major and unnecessary tissue damage. If the underlying event inducing inflammation is not addressed and homeostasis is not restored, this process can become chronic and lead to angiogenesis and carcinogenesis. Thrombospondin-1 (TSP-1) is a matricellular protein involved in angiogenesis, cancer, and inflammation. The effects of TSP-1 have been studied in many preclinical tumor models, and mimetic peptides are being tested in cancer clinical trials. However, the molecular mechanisms explaining its role in inflammatory processes are not well understood. This paper will discuss the role of TSP-1 in inflammation and its interaction with key receptors that may explain its functions in that process. Recent literature will be reviewed showing novel mechanisms by which this multifaceted protein could modulate the inflammatory process and impact its resolution. |
| format | Article |
| id | doaj-art-ee2f6ce1cad144d78723b6b4d8edf3eb |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ee2f6ce1cad144d78723b6b4d8edf3eb2025-02-03T06:08:36ZengWileyMediators of Inflammation0962-93511466-18612011-01-01201110.1155/2011/296069296069Thrombospondin-1: Multiple Paths to InflammationZenaida Lopez-Dee0Kenneth Pidcock1Linda S. Gutierrez2Department of Biology, Wilkes University, Wilkes-Barre, PA 18766, USADepartment of Biology, Wilkes University, Wilkes-Barre, PA 18766, USADepartment of Biology, Wilkes University, Wilkes-Barre, PA 18766, USAInflammation is a defensive process against tissue injury. Once this self-protective strategy is initiated, an effective resolution of the process is crucial to avoid major and unnecessary tissue damage. If the underlying event inducing inflammation is not addressed and homeostasis is not restored, this process can become chronic and lead to angiogenesis and carcinogenesis. Thrombospondin-1 (TSP-1) is a matricellular protein involved in angiogenesis, cancer, and inflammation. The effects of TSP-1 have been studied in many preclinical tumor models, and mimetic peptides are being tested in cancer clinical trials. However, the molecular mechanisms explaining its role in inflammatory processes are not well understood. This paper will discuss the role of TSP-1 in inflammation and its interaction with key receptors that may explain its functions in that process. Recent literature will be reviewed showing novel mechanisms by which this multifaceted protein could modulate the inflammatory process and impact its resolution.http://dx.doi.org/10.1155/2011/296069 |
| spellingShingle | Zenaida Lopez-Dee Kenneth Pidcock Linda S. Gutierrez Thrombospondin-1: Multiple Paths to Inflammation Mediators of Inflammation |
| title | Thrombospondin-1: Multiple Paths to Inflammation |
| title_full | Thrombospondin-1: Multiple Paths to Inflammation |
| title_fullStr | Thrombospondin-1: Multiple Paths to Inflammation |
| title_full_unstemmed | Thrombospondin-1: Multiple Paths to Inflammation |
| title_short | Thrombospondin-1: Multiple Paths to Inflammation |
| title_sort | thrombospondin 1 multiple paths to inflammation |
| url | http://dx.doi.org/10.1155/2011/296069 |
| work_keys_str_mv | AT zenaidalopezdee thrombospondin1multiplepathstoinflammation AT kennethpidcock thrombospondin1multiplepathstoinflammation AT lindasgutierrez thrombospondin1multiplepathstoinflammation |