Endoscopic Ultrasound-Guided Intratumoural Therapy for Pancreatic Cancer
Pancreatic cancer is the second most frequent gastrointestinal malignancy and carries a dismal prognosis. The current standard of care includes resection, if possible, as well as systemic chemoradiation therapy. Endoscopic ultrasound (EUS) is an established technique for the diagnosis and staging of...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2008/104398 |
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| _version_ | 1832560356638064640 |
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| author | Brian M Yan Jacques Van Dam |
| author_facet | Brian M Yan Jacques Van Dam |
| author_sort | Brian M Yan |
| collection | DOAJ |
| description | Pancreatic cancer is the second most frequent gastrointestinal malignancy and carries a dismal prognosis. The current standard of care includes resection, if possible, as well as systemic chemoradiation therapy. Endoscopic ultrasound (EUS) is an established technique for the diagnosis and staging of pancreatic adenocarcinoma. Interventional EUS via fine needle injection (FNI) for the treatment of pancreatic cancer is a rapidly expanding field. The present article reviews the up-to-date developments in EUS FNI for intratumoural pancreatic cancer therapy, including antitumoural agents, immunotherapy, ablative techniques and new delivery systems. The therapeutic modalities discussed are currently under development and will hopefully reach clinical practice if benefit is demonstrated through clinical trials. EUS FNI may be an exciting new technique for the delivery of desperately needed novel therapies for pancreatic cancer. |
| format | Article |
| id | doaj-art-ee115abd0bf64fc99448e0f15bb93b71 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-ee115abd0bf64fc99448e0f15bb93b712025-02-03T01:27:49ZengWileyCanadian Journal of Gastroenterology0835-79002008-01-0122440541010.1155/2008/104398Endoscopic Ultrasound-Guided Intratumoural Therapy for Pancreatic CancerBrian M Yan0Jacques Van Dam1Division of Gastroenterology, University of Calgary, Calgary, Alberta, CanadaDivision of Gastroenterology, Department of Medicine, Stanford University Medical Center, Stanford, California, USAPancreatic cancer is the second most frequent gastrointestinal malignancy and carries a dismal prognosis. The current standard of care includes resection, if possible, as well as systemic chemoradiation therapy. Endoscopic ultrasound (EUS) is an established technique for the diagnosis and staging of pancreatic adenocarcinoma. Interventional EUS via fine needle injection (FNI) for the treatment of pancreatic cancer is a rapidly expanding field. The present article reviews the up-to-date developments in EUS FNI for intratumoural pancreatic cancer therapy, including antitumoural agents, immunotherapy, ablative techniques and new delivery systems. The therapeutic modalities discussed are currently under development and will hopefully reach clinical practice if benefit is demonstrated through clinical trials. EUS FNI may be an exciting new technique for the delivery of desperately needed novel therapies for pancreatic cancer.http://dx.doi.org/10.1155/2008/104398 |
| spellingShingle | Brian M Yan Jacques Van Dam Endoscopic Ultrasound-Guided Intratumoural Therapy for Pancreatic Cancer Canadian Journal of Gastroenterology |
| title | Endoscopic Ultrasound-Guided Intratumoural Therapy for Pancreatic Cancer |
| title_full | Endoscopic Ultrasound-Guided Intratumoural Therapy for Pancreatic Cancer |
| title_fullStr | Endoscopic Ultrasound-Guided Intratumoural Therapy for Pancreatic Cancer |
| title_full_unstemmed | Endoscopic Ultrasound-Guided Intratumoural Therapy for Pancreatic Cancer |
| title_short | Endoscopic Ultrasound-Guided Intratumoural Therapy for Pancreatic Cancer |
| title_sort | endoscopic ultrasound guided intratumoural therapy for pancreatic cancer |
| url | http://dx.doi.org/10.1155/2008/104398 |
| work_keys_str_mv | AT brianmyan endoscopicultrasoundguidedintratumouraltherapyforpancreaticcancer AT jacquesvandam endoscopicultrasoundguidedintratumouraltherapyforpancreaticcancer |