Risk factors for CAR T-cell manufacturing failure and patient outcomes in large B-cell lymphoma: a report from the UK National CAR T Panel

Risk factors for CAR T-cell manufacturing failure and patient outcomes in large B-cell lymphoma: a report from the UK National CAR T Panel

Abstract CAR T-cell manufacturing failure (MF) is a situation where the manufacturing process fails to yield a product or results in one which is out-of-specification (OOS). We conducted a multicentre retrospective review of factors contributing to MF and patient outcomes. Of 981 large B-cell lympho...

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Main Authors: Vaishali Dulobdas, Amy A. Kirkwood, Fabio Serpenti, Brijesh Gautama, Aikaterini Panopoulou, Amrith Mathew, Sumantha Gabriel, Ram Malladi, Jessica Pealing, Denise Bonney, Emma Nicholson, Caroline Besley, Sara Ghorashian, Andrea Kuhnl, Elizabeth Davies, Jackie Chappell, Anne Black, Tobias Menne, Maeve A. O’Reilly, Robin Sanderson, Sridhar Chaganti
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-025-01225-9
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https://doi.org/10.1038/s41408-025-01225-9

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