Editorial: Targeting the interleukin-1β/interleukin-6/C-reactive protein pathway in clinical medicine - a road map to clinical trial design

Editorial: Targeting the interleukin-1β/interleukin-6/C-reactive protein pathway in clinical medicine - a road map to clinical trial design

Saved in:

Bibliographic Details
Main Authors:	Jan Torzewski, Ahmed Sheriff, Janos G. Filep, Karlheinz Peter, Paul M. Ridker
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	interleukin-1ß (IL-1ß) interleukin-6 (IL-6) C-reactive protein cardiovascular disease clinical trial
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2025.1644576/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Effects of combined cyclosporin and azithromycin treatment on human mononuclear cells under lipopolysaccharide challenge
by: Norah Alotaibi, et al.
Published: (2025-03-01)

C-reactive protein conformations and their association with the IL-1β/IL-6 pathway in ocular inflammatory conditions
by: Mercedes S. Nabaes Jodar, et al.
Published: (2025-05-01)

Interleukin-6-induced neuroinflammation is exacerbated by subclinical levels of interferon-α
by: Pattama Songkhunawej, et al.
Published: (2025-06-01)

Immunohistochemical expression of IL-1β, IL-6, and NF-κβ in fibroids
by: Mateusz de Mezer, et al.
Published: (2025-07-01)

Role of interleukins in heart failure with reduced ejection fraction
by: Oliwia Anna Segiet, et al.
Published: (2019-11-01)

Correlations of interleukin levels with the severity of SARS-CoV-2 coronavirus infection
by: O. N. Yashkina, et al.
Published: (2023-04-01)

Deficiency of interleukin-1 receptor antagonist: An updated review of the pathogenesis, clinical characteristics, and treatments
by: Spencer Fang, et al.
Published: (2024-12-01)

Clinical experience with the interleukin-1β blocker canakinumab in patients with chronic tophaceous gout: abolishment of arthritis and prevention of exacerbations when allopurinol is used
by: M. S. Eliseev, et al.
Published: (2015-06-01)

Expression of interleukin 1-alpha, interleukin 6 and CD 10 in predicting recurrence of ameloblastoma
by: Nurhazwani Mohd Danil, et al.
Published: (2025-07-01)

Triptolide suppresses IL-1β-induced expression of interleukin-8 by inhibiting ROS-Mediated ERK, AP-1, and NF-κB molecules in human gastric cancer AGS cells
by: Shinan Li, et al.
Published: (2025-01-01)

Cytokine tatus in patients with recurrent herpes infection
by: A. S. Akmeeva, et al.
Published: (2021-08-01)

Diagnostic Value of C-Reactive Protein and Interleukin-6 in Prevention of Negative Appendectomy
by: H Layegh, et al.
Published: (2024-03-01)

An Evaluation of the Levels of IL-1β and IL-7 in Children With Viral Gastroenteritis
by: Saja Mohammed Mohsen, et al.
Published: (2025-05-01)

The role of interleukin-6 classic and trans-signaling and interleukin-11 classic signaling in gastric cancer cells
by: Josephine Runge, et al.
Published: (2024-08-01)

Evaluation of CRP SNV rs2808630 and acute proinflammatory biomarkers in patients with CKD and PLHIV with CKD: a case-control study
by: Andrea Torres-Rojas, et al.
Published: (2025-05-01)

Macrophage immune modulation: TGF-β1's influence on IL-1β dynamics in dengue virus infection
by: Javier Serrato Salas, et al.
Published: (2025-03-01)

Interleukin-6 versus C-reactive protein as markers for early detection of bacteremia in febrile neutropenia in pediatric population
by: Manasi Gupta, et al.
Published: (2020-01-01)

The Significance of Serum and Fecal Levels of Interleukin-6 and Interleukin-8 in Hospitalized Children with Acute Rotavirus and Norovirus Gastroenteritis
by: Shan-Ming Chen, et al.
Published: (2014-04-01)

Study the Serum IL-6 Level between Rheumatoid Arthritis Patients and Control
by: Semaa Abdulrahman Shaban
Published: (2023-02-01)

The Impact of Interleukin-6 and Hypoxia on the Expression of Brain Injury Marker Proteins in a Cellular Model of the Neurovascular Unit
by: A. A. Ivkin, et al.
Published: (2025-06-01)

N-acetylcysteine reduces the hepatic complications of social isolation stress through modulation of interleukin 1 and 6 gene expression and liver enzymes in mice
by: Javad Asgharzadeh, et al.
Published: (2025-07-01)

Plasma levels of C-reactive protein and Interleukin-6 as markers of inflammation in patients with operative treated fractures
by: Hristijan Kostov, et al.
Published: (2024-10-01)

Independent role of interleukin interleukin-6 and interleukin-8 in the etiology of transfusion reactions to platelet concentrates in children
by: Šerbić-Nonković Olivera, et al.
Published: (2018-01-01)

Genetic Variants of Interleukin-8 and Interleukin-16 and Their Association with Cervical Cancer Risk
by: Rafał Watrowski, et al.
Published: (2025-01-01)

Selection of excipients for the purpose of creating an intranasal gel of interleukin-1 receptor antagonist β (IL-1ra)
by: B. S. Burlaka, et al.
Published: (2020-08-01)

Impact of Delayed Centrifugation on Interleukin 6 Determination in Human Blood
by: Hannah L. Sauerwein, et al.
Published: (2025-05-01)

Detection of interleukin-6 and interleukin-8 in serum from women with recurrent spontaneous abortion
by: Baghdad Science Journal
Published: (2010-09-01)

Deficiency of the interleukin-1 receptor antagonist: Characterizing the molecular consequences of loss-of-function IL1RN variants from structural and biochemical evidence
by: Joshua Pillai, et al.
Published: (2025-06-01)

Nano-curcumin Effects on Ischemic Stroke clinical outcomes and Interleukin-6 Levels: Pilot Randomized Clinical Trial
by: Zeinab Ehtiatkar, et al.
Published: (2025-01-01)

Pattern of Interleukin-17A and Interleukin-1β in Migraine Patients
by: Fardin Faraji, et al.
Published: (2024-08-01)

A clinical case of adult-onset Still's disease resistant to therapy with tumor necrosis factor-alpha inhibitors and interleukin-6 inhibitors
by: R. R. Samigullina, et al.
Published: (2019-03-01)

ASSOCIATION OF rs4537545 (C>T) ALLELE POLYMORPHISM IN THE IL6R GENE WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS
by: L. V. Topchieva, et al.
Published: (2020-06-01)

The Differences Between Interleukin-6 and C-reactive Protein Levels Among Adult Patients of Dengue Infection with and without Plasma Leakage
by: Eppy Eppy, et al.
Published: (2016-09-01)

The Differences Between Interleukin-6 and C-reactive Protein Levels Among Adult Patients of Dengue Infection with and without Plasma Leakage
by: Eppy Eppy, et al.
Published: (2016-09-01)

Effective management of pediatric septic shock: a case study utilizing continuous renal replacement therapy with cytosorb and citrate in a leukemic patient with hyper-interleukin (IL)-6-naemia and severe thrombocytopenia
by: Amir Saeed, et al.
Published: (2025-03-01)

Comparison of spleen characterization and plasma levels of interleukin 6 and 10 in obese and healthy individuals
by: Mahdis Tanzifi, et al.
Published: (2024-12-01)

INVESTIGATION OF CYTOKINE PROFILE IN PATIENTS WITH REACTIVE ARTHRITIS
by: T. V. Gaponova, et al.
Published: (2014-07-01)

Cardiometabolic risk factors and their relationship with the interleukin-6 receptor gene polymorphism (rs2228145) in patients with hypertrophic cardiomyopathy
by: T. G. Bezhanishvili, et al.
Published: (2020-11-01)

Employing Multi-Omics Analyses to Understand Changes during Kidney Development in Perinatal Interleukin-6 Animal Model
by: Ganesh Panzade, et al.
Published: (2024-10-01)

Neutrophil extracellular traps and interleukin-1β in cystic fibrosis lung disease
by: Kayla M. Fantone, et al.
Published: (2025-07-01)