VSL#3 Probiotic Upregulates Intestinal Mucosal Alkaline Sphingomyelinase and Reduces Inflammation
BACKGROUND: Alkaline sphingomyelinase, an enzyme found exclusively in bile and the intestinal brush border, hydrolyzes sphingomyelin into ceramide, sphingosine and sphingosine-1-phosphate, thereby inducing epithelial apoptosis. Reduced levels of alkaline sphingomyelinase have been found in premalign...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2008/520383 |
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| _version_ | 1832553367962910720 |
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| author | Isaac Soo Karen L Madsen Qassim Tejpar Beate C Sydora Richard Sherbaniuk Benedetta Cinque Luisa Di Marzio Maria Grazia Cifone Claudio Desimone Richard N Fedorak |
| author_facet | Isaac Soo Karen L Madsen Qassim Tejpar Beate C Sydora Richard Sherbaniuk Benedetta Cinque Luisa Di Marzio Maria Grazia Cifone Claudio Desimone Richard N Fedorak |
| author_sort | Isaac Soo |
| collection | DOAJ |
| description | BACKGROUND: Alkaline sphingomyelinase, an enzyme found exclusively in bile and the intestinal brush border, hydrolyzes sphingomyelin into ceramide, sphingosine and sphingosine-1-phosphate, thereby inducing epithelial apoptosis. Reduced levels of alkaline sphingomyelinase have been found in premalignant and malignant intestinal epithelia and in ulcerative colitis tissue. Probiotic bacteria can be a source of sphingomyelinase. |
| format | Article |
| id | doaj-art-ede3438b5bfb4297b065c93bcf61fcd0 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-ede3438b5bfb4297b065c93bcf61fcd02025-02-03T05:54:12ZengWileyCanadian Journal of Gastroenterology0835-79002008-01-0122323724210.1155/2008/520383VSL#3 Probiotic Upregulates Intestinal Mucosal Alkaline Sphingomyelinase and Reduces InflammationIsaac Soo0Karen L Madsen1Qassim Tejpar2Beate C Sydora3Richard Sherbaniuk4Benedetta Cinque5Luisa Di Marzio6Maria Grazia Cifone7Claudio Desimone8Richard N Fedorak9Division of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaDivision of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaDivision of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaDivision of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaDivision of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaDepartment of Experimental Medicine, University of L’Aquila, L’Aquila, ItalyDepartment of Drug Science, University G D’Annunzio, Chieti, ItalyDepartment of Experimental Medicine, University of L’Aquila, L’Aquila, ItalyDepartment of Experimental Medicine, University of L’Aquila, L’Aquila, ItalyDivision of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaBACKGROUND: Alkaline sphingomyelinase, an enzyme found exclusively in bile and the intestinal brush border, hydrolyzes sphingomyelin into ceramide, sphingosine and sphingosine-1-phosphate, thereby inducing epithelial apoptosis. Reduced levels of alkaline sphingomyelinase have been found in premalignant and malignant intestinal epithelia and in ulcerative colitis tissue. Probiotic bacteria can be a source of sphingomyelinase.http://dx.doi.org/10.1155/2008/520383 |
| spellingShingle | Isaac Soo Karen L Madsen Qassim Tejpar Beate C Sydora Richard Sherbaniuk Benedetta Cinque Luisa Di Marzio Maria Grazia Cifone Claudio Desimone Richard N Fedorak VSL#3 Probiotic Upregulates Intestinal Mucosal Alkaline Sphingomyelinase and Reduces Inflammation Canadian Journal of Gastroenterology |
| title | VSL#3 Probiotic Upregulates Intestinal Mucosal Alkaline Sphingomyelinase and Reduces Inflammation |
| title_full | VSL#3 Probiotic Upregulates Intestinal Mucosal Alkaline Sphingomyelinase and Reduces Inflammation |
| title_fullStr | VSL#3 Probiotic Upregulates Intestinal Mucosal Alkaline Sphingomyelinase and Reduces Inflammation |
| title_full_unstemmed | VSL#3 Probiotic Upregulates Intestinal Mucosal Alkaline Sphingomyelinase and Reduces Inflammation |
| title_short | VSL#3 Probiotic Upregulates Intestinal Mucosal Alkaline Sphingomyelinase and Reduces Inflammation |
| title_sort | vsl 3 probiotic upregulates intestinal mucosal alkaline sphingomyelinase and reduces inflammation |
| url | http://dx.doi.org/10.1155/2008/520383 |
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