Dual fragmentation via collision-induced and oxygen attachment dissociations using water and its radicals for C=C position-resolved lipidomics

Abstract Oxygen attachment dissociation (OAD) is a tandem mass spectrometry (MS/MS) technique for annotating the positions of double bonds (C=C) in complex lipids. Although OAD has been used for untargeted lipidomics, its availability has been limited to the positive ion mode, requiring the independ...

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Bibliographic Details
Main Authors: Hiroaki Takeda, Mami Okamoto, Hidenori Takahashi, Bujinlkham Buyantogtokh, Noriyuki Kishi, Hideyuki Okano, Hiroyuki Kamiguchi, Hiroshi Tsugawa
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01525-y
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