Creatinine-Based Estimations of Kidney Function Are Unreliable in Obese Kidney Donors
Accurate assessment of kidney function by measurement of glomerular filtration rate (GFR) is essential to the risk assessment of prospective living kidney donors. We evaluated the performance of various estimating equations for creatinine clearance (Cockcroft-Gault), GFR (Modification of Diet in Ren...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2012/872894 |
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| author | Nidhi Aggarwal Anna C. Porter Ignatius Y. S. Tang Bryan N. Becker Sanjeev K. Akkina |
| author_facet | Nidhi Aggarwal Anna C. Porter Ignatius Y. S. Tang Bryan N. Becker Sanjeev K. Akkina |
| author_sort | Nidhi Aggarwal |
| collection | DOAJ |
| description | Accurate assessment of kidney function by measurement of glomerular filtration rate (GFR) is essential to the risk assessment of prospective living kidney donors. We evaluated the performance of various estimating equations for creatinine clearance (Cockcroft-Gault), GFR (Modification of Diet in Renal Disease, Chronic Kidney Disease Epidemiology Collaboration), and 24-hour urine collections for creatinine clearance in obese potential kidney donors. We evaluated 164 potential kidney donors including 49 with a BMI of 30–35 and 32 with a BMI >35 that have completed a routine living donor evaluation with a measured GFR. All the estimating equations performed poorly in obese donors. While 24-hour urine collections performed better, only 15% had an adequate 24-hour urine collection. Since obese kidney donors may be at higher than average risk for kidney failure, accurate assessment of kidney function in these donors is crucial to ensure their long-term health postdonation. |
| format | Article |
| id | doaj-art-ed8dadf524794e9dba7f41da79d8de56 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-ed8dadf524794e9dba7f41da79d8de562025-02-03T00:59:14ZengWileyJournal of Transplantation2090-00072090-00152012-01-01201210.1155/2012/872894872894Creatinine-Based Estimations of Kidney Function Are Unreliable in Obese Kidney DonorsNidhi Aggarwal0Anna C. Porter1Ignatius Y. S. Tang2Bryan N. Becker3Sanjeev K. Akkina4Department of Medicine, University of Illinois at Chicago, 820 S. Wood Street, M/C 793, Chicago, IL 60612-7315, USADepartment of Medicine, University of Illinois at Chicago, 820 S. Wood Street, M/C 793, Chicago, IL 60612-7315, USADepartment of Medicine, University of Illinois at Chicago, 820 S. Wood Street, M/C 793, Chicago, IL 60612-7315, USADepartment of Medicine, University of Illinois at Chicago, 820 S. Wood Street, M/C 793, Chicago, IL 60612-7315, USADepartment of Medicine, University of Illinois at Chicago, 820 S. Wood Street, M/C 793, Chicago, IL 60612-7315, USAAccurate assessment of kidney function by measurement of glomerular filtration rate (GFR) is essential to the risk assessment of prospective living kidney donors. We evaluated the performance of various estimating equations for creatinine clearance (Cockcroft-Gault), GFR (Modification of Diet in Renal Disease, Chronic Kidney Disease Epidemiology Collaboration), and 24-hour urine collections for creatinine clearance in obese potential kidney donors. We evaluated 164 potential kidney donors including 49 with a BMI of 30–35 and 32 with a BMI >35 that have completed a routine living donor evaluation with a measured GFR. All the estimating equations performed poorly in obese donors. While 24-hour urine collections performed better, only 15% had an adequate 24-hour urine collection. Since obese kidney donors may be at higher than average risk for kidney failure, accurate assessment of kidney function in these donors is crucial to ensure their long-term health postdonation.http://dx.doi.org/10.1155/2012/872894 |
| spellingShingle | Nidhi Aggarwal Anna C. Porter Ignatius Y. S. Tang Bryan N. Becker Sanjeev K. Akkina Creatinine-Based Estimations of Kidney Function Are Unreliable in Obese Kidney Donors Journal of Transplantation |
| title | Creatinine-Based Estimations of Kidney Function Are Unreliable in Obese Kidney Donors |
| title_full | Creatinine-Based Estimations of Kidney Function Are Unreliable in Obese Kidney Donors |
| title_fullStr | Creatinine-Based Estimations of Kidney Function Are Unreliable in Obese Kidney Donors |
| title_full_unstemmed | Creatinine-Based Estimations of Kidney Function Are Unreliable in Obese Kidney Donors |
| title_short | Creatinine-Based Estimations of Kidney Function Are Unreliable in Obese Kidney Donors |
| title_sort | creatinine based estimations of kidney function are unreliable in obese kidney donors |
| url | http://dx.doi.org/10.1155/2012/872894 |
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