Intranasal recombinant protein subunit vaccine targeting TLR3 induces respiratory tract IgA and CD8 T cell responses and protects against respiratory virus infectionResearch in context

Intranasal recombinant protein subunit vaccine targeting TLR3 induces respiratory tract IgA and CD8 T cell responses and protects against respiratory virus infectionResearch in context

Summary: Background: Intranasal vaccines against respiratory viruses are desired due to ease of administration and potential to protect against virus infection of the upper respiratory tract. Methods: We tested a cationic liposomal adjuvant delivering the TLR3 agonist Poly (I:C) (CAF®09b) for intra...

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Main Authors: Katharina Wørzner, Signe Tandrup Schmidt, Julie Zimmermann, Ahmad Tami, Charlotta Polacek, Carlota Fernandez-Antunez, Katrine Top Hartmann, Rune Fledelius Jensen, Julia Sid Hansen, Kristin Illigen, Louise Krag Isling, Gitte Erbs, Gregers Jungersen, Ida Rosenkrands, Anna Offersgaard, Judith Gottwein, Kenn Holmbeck, Henrik Elvang Jensen, Santseharay Ramirez, Frank Follmann, Jens Bukh, Gabriel Kristian Pedersen
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:EBioMedicine
Subjects:
SARS-CoV-2
CAF®09b
CD8 T cells
Intranasal vaccine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425000593
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