Steatohepatitis-induced vascular niche alterations promote melanoma metastasis

Steatohepatitis-induced vascular niche alterations promote melanoma metastasis

Abstract Background In malignant melanoma, liver metastases significantly reduce survival, even despite highly effective new therapies. Given the increase in metabolic liver diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatoh...

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Main Authors: Johannes Hoffmann, Julia Schüler, Bianca Dietsch, Sina Wietje Kürschner-Zacharias, Carsten Sticht, Felix A. Trogisch, Maren Schreitmüller, Tinja Baljkas, Kai Schledzewski, Manuel Reinhart, Sebastian A. Wohlfeil, Manuel Winkler, Christian David Schmid, Joerg Heineke, Cyrill Géraud, Sergij Goerdt, Philipp-Sebastian Reiners-Koch, Victor Olsavszky
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cancer & Metabolism
Subjects:
Cutaneous malignant melanoma
Hepatic metastasis
Metabolic dysfunction-associated steatohepatitis
Early vascular alterations
Liver sinusoidal endothelial cells
Online Access:https://doi.org/10.1186/s40170-025-00374-6
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https://doi.org/10.1186/s40170-025-00374-6

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