MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

Abstract Lactate plays diverse roles in brain pathophysiology, including ischemic stroke. Here, the role of lysine lactylation, an epigenetic modification of lactate, in cerebral ischemia is investigated. Using a mouse model of transient middle cerebral artery occlusion, increased brain lactate leve...

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Main Authors: Min Sun, Yuxin Zhang, Rui Mao, Yan Chen, Pinyi Liu, Lei Ye, Siyi Xu, Junqiu Jia, Shu Shu, Huiya Li, Yanping Yin, Shengnan Xia, Yanting Chen, Yun Xu
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
ischemic stroke
lactylation
MeCP2 lactylation
neuronal apoptosis
transcriptional regulation
Online Access:https://doi.org/10.1002/advs.202415309
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https://doi.org/10.1002/advs.202415309

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