Synthesis and Evaluation of Some New Isoquine Analogues for Antimalarial Activity

Synthesis and Evaluation of Some New Isoquine Analogues for Antimalarial Activity

Amodiaquine is a 4-aminoquinoline antimalarial that can cause adverse side effects including hepatic and haematological toxicity. The drug toxicity involves the formation of an electrophilic metabolite, amodiaquine quinoneimine (AQQI), which binds to cellular macromolecules leading to hepatotoxicity...

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Bibliographic Details
Main Authors:	Chandra Nath Saha, Sanjib Bhattacharya, Dipak Chetia
Format:	Article
Language:	English
Published:	Wiley 2009-01-01
Series:	E-Journal of Chemistry
Online Access:	http://dx.doi.org/10.1155/2009/693757
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