Quantitative analysis of transient and sustained transforming growth factor‐β signaling dynamics

Quantitative analysis of transient and sustained transforming growth factor‐β signaling dynamics

Abstract Mammalian cells can decode the concentration of extracellular transforming growth factor‐β (TGF‐β) and transduce this cue into appropriate cell fate decisions. How variable TGF‐β ligand doses quantitatively control intracellular signaling dynamics and how continuous ligand doses are transla...

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Bibliographic Details
Main Authors: Zhike Zi, Zipei Feng, Douglas A Chapnick, Markus Dahl, Difan Deng, Edda Klipp, Aristidis Moustakas, Xuedong Liu
Format: Article
Language:English
Published: Springer Nature 2011-05-01
Series:Molecular Systems Biology
Subjects:
mathematical model
Smad
TGF‐β
ultrasensitivity
Online Access:https://doi.org/10.1038/msb.2011.22
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https://doi.org/10.1038/msb.2011.22

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