Effects of human immunoglobulin A on Cryptococcus neoformans morphology and gene expression

Effects of human immunoglobulin A on Cryptococcus neoformans morphology and gene expression

ABSTRACT Human IgM was previously shown to inhibit Titan-like cell formation of Cryptococcus neoformans, whereas IgG did not. Here, we conducted an in-depth analysis of the effect of normal human IgA on C. neoformans biology (strain H99) and compared it to that of IgG and IgM. We found that like IgM...

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Main Authors: Nuria Trevijano-Contador, Haroldo C. de Oliveira, Claudia Malacatus-Bravo, Varona Sarai, Isabel Cuesta, Marcio L. Rodrigues, Óscar Zaragoza, Liise-anne Pirofski
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:Microbiology Spectrum
Subjects:
Cryptococcus neoformans
human immunoglobulin
IgA
IgG
IgM
Titan-like cells
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02008-24
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https://journals.asm.org/doi/10.1128/spectrum.02008-24

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