Unravelling the mode of action of the Tres Cantos Antimalarial Set (TCAMS): investigating the mechanism of potent antimalarial compounds potentially targeting the human serotonin receptor

Unravelling the mode of action of the Tres Cantos Antimalarial Set (TCAMS): investigating the mechanism of potent antimalarial compounds potentially targeting the human serotonin receptor

Abstract Background Despite the strides made in recent decades, the resistance observed in existing antimalarial drugs, and the intricate life cycle of the Plasmodium parasite underscore the pressing need to develop novel and effective therapeutic interventions. This article provides a comprehensive...

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Main Authors: Benedito Matheus dos Santos, Lenna Rosanie Cordero Mallaupoma, Mateus Fila Pecenin, Abhinab Mohanty, Angela Lu, Paula J. Bartlett, Andrew P. Thomas, Francisco-Javier Gamo, Celia R. S. Garcia
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Malaria Journal
Subjects:
Antimalarial
Melatonin
Plasmodium falciparum
Serotonin
TCAMS
Online Access:https://doi.org/10.1186/s12936-025-05271-3
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https://doi.org/10.1186/s12936-025-05271-3

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