Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls
Objective. The aim of this study was to compare retinal nerve fiber layer thickness (RNFLT) between spectral-domain (SD-) and time-domain optical coherence tomography (TD-OCT) in MS patients and healthy controls (HC). Furthermore, RNFLT between MS eyes with and without optic neuritis (ON) and HC sh...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2012/564627 |
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| author | Alex P. Lange Reza Sadjadi Jameelah Saeedi Janette Lindley Fiona Costello Anthony L. Traboulsee |
| author_facet | Alex P. Lange Reza Sadjadi Jameelah Saeedi Janette Lindley Fiona Costello Anthony L. Traboulsee |
| author_sort | Alex P. Lange |
| collection | DOAJ |
| description | Objective. The aim of this study was to compare retinal nerve fiber layer thickness (RNFLT) between spectral-domain (SD-) and time-domain optical coherence tomography (TD-OCT) in MS patients and healthy controls (HC). Furthermore, RNFLT between MS eyes with and without optic neuritis (ON) and HC should be explored. Finally, the relationship between RNFLT, disease duration, EDSS, and disease modifying therapy (DMT) should be established. Design. Prospective, cross-sectional study. Participants. 28 MS patients and 35 HC. Methods. Both groups underwent TD- and SD-OCT measurements. RFNLT was correlated between the two machines and between MS eyes with and without ON and HC. Furthermore, RNFLT was correlated to disease duration, EDSS and DMT. Results. A strong correlation (Pearson’s r=0.921, P<0.001), but a statistically significant difference of 2 μm (P<0.001), was found between the two devices. RNFLT was significantly different between MS eyes with history of ON (mean RFNLT (SD) 72.21 μm (15.83 μm)), MS eyes without history of ON 93.03 μm (14.25 μm), and HC 99.07 μm (7.23 μm) (P<0.001). Conclusions. The measurements between different generation of OCT machines are not interchangeable, which should be taken into account if comparing results between different machines and switching OCT machine in longitudinal studies. |
| format | Article |
| id | doaj-art-ecc2c3fc2f144ad2a16c52fc384d25d4 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-ecc2c3fc2f144ad2a16c52fc384d25d42025-02-03T01:03:08ZengWileyJournal of Ophthalmology2090-004X2090-00582012-01-01201210.1155/2012/564627564627Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy ControlsAlex P. Lange0Reza Sadjadi1Jameelah Saeedi2Janette Lindley3Fiona Costello4Anthony L. Traboulsee5Neuro-Ophthalmology Division, Department of Ophthalmology, Eye Care Center (VGH), The University of British Columbia, 2550 Willow Street, Vancouver, BC, V5Z 3N9, CanadaDivision of Neurology, Department of Medicine, University of British Columbia, S199 Koerner Pavillion, Wesbrook Mall, Vancouver, BC, V6T 2B5, CanadaDivision of Neurology, Department of Medicine, University of British Columbia, S199 Koerner Pavillion, Wesbrook Mall, Vancouver, BC, V6T 2B5, CanadaNeuro-Ophthalmology Division, Department of Ophthalmology, Eye Care Center (VGH), The University of British Columbia, 2550 Willow Street, Vancouver, BC, V5Z 3N9, CanadaDepartments of Clinical Neurosciences and Surgery and Hotchkiss Brain Institute, University of Calgary, Calgary, AB, T2N 1N4, CanadaDivision of Neurology, Department of Medicine, University of British Columbia, S199 Koerner Pavillion, Wesbrook Mall, Vancouver, BC, V6T 2B5, CanadaObjective. The aim of this study was to compare retinal nerve fiber layer thickness (RNFLT) between spectral-domain (SD-) and time-domain optical coherence tomography (TD-OCT) in MS patients and healthy controls (HC). Furthermore, RNFLT between MS eyes with and without optic neuritis (ON) and HC should be explored. Finally, the relationship between RNFLT, disease duration, EDSS, and disease modifying therapy (DMT) should be established. Design. Prospective, cross-sectional study. Participants. 28 MS patients and 35 HC. Methods. Both groups underwent TD- and SD-OCT measurements. RFNLT was correlated between the two machines and between MS eyes with and without ON and HC. Furthermore, RNFLT was correlated to disease duration, EDSS and DMT. Results. A strong correlation (Pearson’s r=0.921, P<0.001), but a statistically significant difference of 2 μm (P<0.001), was found between the two devices. RNFLT was significantly different between MS eyes with history of ON (mean RFNLT (SD) 72.21 μm (15.83 μm)), MS eyes without history of ON 93.03 μm (14.25 μm), and HC 99.07 μm (7.23 μm) (P<0.001). Conclusions. The measurements between different generation of OCT machines are not interchangeable, which should be taken into account if comparing results between different machines and switching OCT machine in longitudinal studies.http://dx.doi.org/10.1155/2012/564627 |
| spellingShingle | Alex P. Lange Reza Sadjadi Jameelah Saeedi Janette Lindley Fiona Costello Anthony L. Traboulsee Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls Journal of Ophthalmology |
| title | Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls |
| title_full | Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls |
| title_fullStr | Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls |
| title_full_unstemmed | Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls |
| title_short | Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls |
| title_sort | time domain and spectral domain optical coherence tomography of retinal nerve fiber layer in ms patients and healthy controls |
| url | http://dx.doi.org/10.1155/2012/564627 |
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