Phenotypic screening uncovered anti-myocardial fibrosis candidates using a novel 3D myocardial tissue under hypoxia

Myocardial fibrosis (MF) is a common pathological hallmark of cardiovascular diseases, reflecting shared mechanisms in their progression. However, the lack of reliable MF models that accurately mimic its pathogenesis has hindered drug discovery, highlighting the urgent need for more effective therap...

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Bibliographic Details
Main Authors: Jingyu Wang, Xiangning Liu, Rongxin Zhu, Ying Sun, Boyang Jiao, Keyan Wang, Yong Jiang, Yong Wang, Chun Li, Wei Wang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Acta Pharmaceutica Sinica B
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525002874
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