Discovery of Cyclopentane-Based Phospholipids as Miltefosine Analogs with Superior Potency and Enhanced Selectivity Against <i>Naegleria fowleri</i>

Discovery of Cyclopentane-Based Phospholipids as Miltefosine Analogs with Superior Potency and Enhanced Selectivity Against <i>Naegleria fowleri</i>

<b>Background/Objectives:</b> <i>Naegleria fowleri</i> is a free-living amoeba that invades brain tissues causing fatal primary amoebic meningoencephalitis (PAM). An effective and tolerable therapeutic agent is still lacking. <b>Methods:</b> A series of conformati...

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Bibliographic Details
Main Authors: Ahmed H. E. Hassan, Hương Giang Lê, Tuấn Cường Võ, Minji Kim, Joo Hwan No, Mohamed H. Aboutaleb, Jaehoon Sim, Byoung-Kuk Na, Yong Sup Lee
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceuticals
Subjects:
<i>Naegleria fowleri</i>
primary amoebic meningoencephalitis
miltefosine analogs
potential drug
Online Access:https://www.mdpi.com/1424-8247/18/7/984
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