A variety of clinical presentations of eosinophilic granulomatosis with polyangiitis: a comprehensive review
Introduction Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by eosinophilic granulomatous vasculitis. Typical symptoms include late-onset bronchial asthma and blood and tissue eosinophilia. In addition to these characteristic symptoms, EGPA can affect important organs such as...
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Termedia Publishing House
2024-12-01
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| Series: | Rheumatology |
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| Online Access: | https://reu.termedia.pl/A-variety-of-clinical-presentations-of-eosinophilic-granulomatosis-with-polyangiitis,196141,0,2.html |
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| _version_ | 1832584829453991936 |
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| author | Agata Sebastian Joanna Kosałka-Węgiel |
| author_facet | Agata Sebastian Joanna Kosałka-Węgiel |
| author_sort | Agata Sebastian |
| collection | DOAJ |
| description | Introduction
Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by eosinophilic granulomatous vasculitis. Typical symptoms include late-onset bronchial asthma and blood and tissue eosinophilia. In addition to these characteristic symptoms, EGPA can affect important organs such as the skin, kidneys, heart, sinuses, gastrointestinal tract, and nervous system. Given the variability of the clinical presentation, EGPA is challenging to diagnose. Furthermore, EGPA often occurs in phases, with clinical manifestations and pathological findings varying depending on the affected anatomic site and stage of disease.
Material and Methods
The authors reviewed the SCOPUS, MEDLINE, and PubMed medical databases to prepare an overview of the clinical manifestations and diagnosis for EGPA.
Results
This comprehensive review examines the current knowledge on the clinical course of EGPA, diagnostic options and prognostic factors.
Conclusions
We highlight the diverse organ involvement observed in EGPA, particularly in association with eosinophilic and vasculitic manifestations. Our findings underscore the importance of anti- neutrophil cytoplasm antibody status as a potential key factor influencing disease presentation. |
| format | Article |
| id | doaj-art-ec9047a5fd4149eea9f5fac098f39c80 |
| institution | Kabale University |
| issn | 0034-6233 2084-9834 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Rheumatology |
| spelling | doaj-art-ec9047a5fd4149eea9f5fac098f39c802025-01-27T11:21:26ZengTermedia Publishing HouseRheumatology0034-62332084-98342024-12-0162645646510.5114/reum/196141196141A variety of clinical presentations of eosinophilic granulomatosis with polyangiitis: a comprehensive reviewAgata Sebastian0https://orcid.org/0000-0001-6332-8714Joanna Kosałka-Węgiel1https://orcid.org/0000-0003-1013-2253Department and Clinic of Rheumatology and Internal Medicine, Wroclaw Medical University, PolandDepartment of Rheumatology and Immunology, Jagiellonian University Medical College, Krakow, PolandIntroduction Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by eosinophilic granulomatous vasculitis. Typical symptoms include late-onset bronchial asthma and blood and tissue eosinophilia. In addition to these characteristic symptoms, EGPA can affect important organs such as the skin, kidneys, heart, sinuses, gastrointestinal tract, and nervous system. Given the variability of the clinical presentation, EGPA is challenging to diagnose. Furthermore, EGPA often occurs in phases, with clinical manifestations and pathological findings varying depending on the affected anatomic site and stage of disease. Material and Methods The authors reviewed the SCOPUS, MEDLINE, and PubMed medical databases to prepare an overview of the clinical manifestations and diagnosis for EGPA. Results This comprehensive review examines the current knowledge on the clinical course of EGPA, diagnostic options and prognostic factors. Conclusions We highlight the diverse organ involvement observed in EGPA, particularly in association with eosinophilic and vasculitic manifestations. Our findings underscore the importance of anti- neutrophil cytoplasm antibody status as a potential key factor influencing disease presentation.https://reu.termedia.pl/A-variety-of-clinical-presentations-of-eosinophilic-granulomatosis-with-polyangiitis,196141,0,2.htmleosinophilic granulomatosis with polyangiitiseosinophiliaanca vasculitis |
| spellingShingle | Agata Sebastian Joanna Kosałka-Węgiel A variety of clinical presentations of eosinophilic granulomatosis with polyangiitis: a comprehensive review Rheumatology eosinophilic granulomatosis with polyangiitis eosinophilia anca vasculitis |
| title | A variety of clinical presentations of eosinophilic granulomatosis with polyangiitis: a comprehensive review |
| title_full | A variety of clinical presentations of eosinophilic granulomatosis with polyangiitis: a comprehensive review |
| title_fullStr | A variety of clinical presentations of eosinophilic granulomatosis with polyangiitis: a comprehensive review |
| title_full_unstemmed | A variety of clinical presentations of eosinophilic granulomatosis with polyangiitis: a comprehensive review |
| title_short | A variety of clinical presentations of eosinophilic granulomatosis with polyangiitis: a comprehensive review |
| title_sort | variety of clinical presentations of eosinophilic granulomatosis with polyangiitis a comprehensive review |
| topic | eosinophilic granulomatosis with polyangiitis eosinophilia anca vasculitis |
| url | https://reu.termedia.pl/A-variety-of-clinical-presentations-of-eosinophilic-granulomatosis-with-polyangiitis,196141,0,2.html |
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