Research on detection methods of related substances and degradation products of the antitumor drug selpercatinib

BackgroundSelpercatinib, a selective RET kinase inhibitor, is approved for treating various cancers with RET gene mutations such as RET-rearranged thyroid cancer and non-small cell lung cancer. The presence of process-related and degradation impurities in its active pharmaceutical ingredient (API) c...

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Bibliographic Details
Main Authors: Jingjing Xiang, Liangliang Cai, Qin Wang, Yonghong Zhu, Yong Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Chemistry
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2024.1534132/full
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