Haemodynamic changes of interatrial shunting devices for heart failure: a systematic review and meta‐analysis
Abstract Aims To assess the efficacy and safety, primarily in relation to the haemodynamic effects, of interatrial shunting devices (ISD) for the treatment of heart failure (HF), we conducted a systematic review and a meta‐analysis. Methods and results We used the MEDLINE, Cochrane Library, Embase,...
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Wiley
2022-06-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.13911 |
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| author | Tieci Yi Min Li Fangfang Fan Lin Qiu Zhi Wang Haoyu Weng Xiaoke Shang Changdong Zhang Wei Ma Yan Zhang Yong Huo |
| author_facet | Tieci Yi Min Li Fangfang Fan Lin Qiu Zhi Wang Haoyu Weng Xiaoke Shang Changdong Zhang Wei Ma Yan Zhang Yong Huo |
| author_sort | Tieci Yi |
| collection | DOAJ |
| description | Abstract Aims To assess the efficacy and safety, primarily in relation to the haemodynamic effects, of interatrial shunting devices (ISD) for the treatment of heart failure (HF), we conducted a systematic review and a meta‐analysis. Methods and results We used the MEDLINE, Cochrane Library, Embase, and PubMed databases to identify clinical studies (published to 4 August 2021) that evaluated the effect of ISD on HF. The primary endpoint was defined as changes in pulmonary capillary wedge pressure (PCWP). Secondary endpoints included (i) other haemodynamic indexes, including cardiac output (CO), right atrial pressure (RAP), and mean pulmonary artery pressure (mPAP) by right heart catheterization, and (ii) change from baseline in 6 min walk distance (6MWD). After a literature search and detailed evaluation, six trials enrolling a total of 203 individuals were included in the quantitative analysis. Pooled analyses showed that after ISD implantation, PCWP decreased by a mean 3.10 mmHg [95% confidence interval (CI) −4.56 to −1.64; I2 = 0%; P < 0.0001]. Overall, CO increased by 0.77 L/min (95% CI 0.02 to 1.52; P = 0.04; I2 = 82%), but there were no significant changes in RAP or mPAP. The mean 6MWD increased by 32.33 m (95% CI 10.74 to 53.92; P = 0.003; I2 = 0) after ISD implantation. Conclusions Interatrial shunting device can effectively reduce PCWP, increase CO and 6MWD, and has no obvious adverse effects on the right heart and pulmonary pressure. Studies with larger sample size and longer follow‐up time are needed for further verification. |
| format | Article |
| id | doaj-art-ec79cd3ad4134ef3ac295bf539445d3f |
| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-ec79cd3ad4134ef3ac295bf539445d3f2025-02-05T05:22:10ZengWileyESC Heart Failure2055-58222022-06-01931987199510.1002/ehf2.13911Haemodynamic changes of interatrial shunting devices for heart failure: a systematic review and meta‐analysisTieci Yi0Min Li1Fangfang Fan2Lin Qiu3Zhi Wang4Haoyu Weng5Xiaoke Shang6Changdong Zhang7Wei Ma8Yan Zhang9Yong Huo10Department of Cardiovascular Disease Peking University First Hospital Beijing ChinaDepartment of Cardiovascular Disease Peking University First Hospital Beijing ChinaDepartment of Cardiovascular Disease Peking University First Hospital Beijing ChinaDepartment of Cardiovascular Disease Peking University First Hospital Beijing ChinaDepartment of Cardiovascular Disease Peking University First Hospital Beijing ChinaDepartment of Cardiovascular Disease Peking University First Hospital Beijing ChinaLaboratory of Cardiovascular Surgery, Union Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaLaboratory of Cardiovascular Surgery, Union Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Cardiovascular Disease Peking University First Hospital Beijing ChinaDepartment of Cardiovascular Disease Peking University First Hospital Beijing ChinaDepartment of Cardiovascular Disease Peking University First Hospital Beijing ChinaAbstract Aims To assess the efficacy and safety, primarily in relation to the haemodynamic effects, of interatrial shunting devices (ISD) for the treatment of heart failure (HF), we conducted a systematic review and a meta‐analysis. Methods and results We used the MEDLINE, Cochrane Library, Embase, and PubMed databases to identify clinical studies (published to 4 August 2021) that evaluated the effect of ISD on HF. The primary endpoint was defined as changes in pulmonary capillary wedge pressure (PCWP). Secondary endpoints included (i) other haemodynamic indexes, including cardiac output (CO), right atrial pressure (RAP), and mean pulmonary artery pressure (mPAP) by right heart catheterization, and (ii) change from baseline in 6 min walk distance (6MWD). After a literature search and detailed evaluation, six trials enrolling a total of 203 individuals were included in the quantitative analysis. Pooled analyses showed that after ISD implantation, PCWP decreased by a mean 3.10 mmHg [95% confidence interval (CI) −4.56 to −1.64; I2 = 0%; P < 0.0001]. Overall, CO increased by 0.77 L/min (95% CI 0.02 to 1.52; P = 0.04; I2 = 82%), but there were no significant changes in RAP or mPAP. The mean 6MWD increased by 32.33 m (95% CI 10.74 to 53.92; P = 0.003; I2 = 0) after ISD implantation. Conclusions Interatrial shunting device can effectively reduce PCWP, increase CO and 6MWD, and has no obvious adverse effects on the right heart and pulmonary pressure. Studies with larger sample size and longer follow‐up time are needed for further verification.https://doi.org/10.1002/ehf2.13911Interatrial shunting devicesHeart failureHaemodynamic changesPulmonary capillary wedge pressureMeta‐analysis |
| spellingShingle | Tieci Yi Min Li Fangfang Fan Lin Qiu Zhi Wang Haoyu Weng Xiaoke Shang Changdong Zhang Wei Ma Yan Zhang Yong Huo Haemodynamic changes of interatrial shunting devices for heart failure: a systematic review and meta‐analysis ESC Heart Failure Interatrial shunting devices Heart failure Haemodynamic changes Pulmonary capillary wedge pressure Meta‐analysis |
| title | Haemodynamic changes of interatrial shunting devices for heart failure: a systematic review and meta‐analysis |
| title_full | Haemodynamic changes of interatrial shunting devices for heart failure: a systematic review and meta‐analysis |
| title_fullStr | Haemodynamic changes of interatrial shunting devices for heart failure: a systematic review and meta‐analysis |
| title_full_unstemmed | Haemodynamic changes of interatrial shunting devices for heart failure: a systematic review and meta‐analysis |
| title_short | Haemodynamic changes of interatrial shunting devices for heart failure: a systematic review and meta‐analysis |
| title_sort | haemodynamic changes of interatrial shunting devices for heart failure a systematic review and meta analysis |
| topic | Interatrial shunting devices Heart failure Haemodynamic changes Pulmonary capillary wedge pressure Meta‐analysis |
| url | https://doi.org/10.1002/ehf2.13911 |
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