Fecal Calprotectin Use in Inflammatory Bowel Disease and Beyond: A Mini-Review
Given the number of inflammatory disorders affecting the gastrointestinal tract directly and indirectly, coupled with the considerable overlap with functional disorders, it is evident that more useful noninvasive diagnostic tests are required to aid with diagnosis. If these tests can also have some...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2015/950286 |
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| author | Bashaar Alibrahim Mohammed I Aljasser Baljinder Salh |
| author_facet | Bashaar Alibrahim Mohammed I Aljasser Baljinder Salh |
| author_sort | Bashaar Alibrahim |
| collection | DOAJ |
| description | Given the number of inflammatory disorders affecting the gastrointestinal tract directly and indirectly, coupled with the considerable overlap with functional disorders, it is evident that more useful noninvasive diagnostic tests are required to aid with diagnosis. If these tests can also have some utility for individual patient follow-up in terms of disease activity and response to treatment, as well as providing forewarning of disease relapse, it would be extremely useful information for the clinician. One recently described test that may fulfill several of these attributes is based on leakage of a mononuclear cell cytoplasmic protein, calprotectin, along the intestinal tract, which can then be quantified in feces. This has been used to distinguish patients exhibiting symptoms of irritable bowel syndrome from patients with inflammatory bowel disease, with a measure of success greater than with currently used techniques. The present article summarizes the experience with this test used in inflammatory bowel disease, as well as a variety of gastrointestinal disorders. |
| format | Article |
| id | doaj-art-ec545b43e12347a9937ae2f892cb44b1 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-ec545b43e12347a9937ae2f892cb44b12025-02-03T05:51:51ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972015-01-0129315716310.1155/2015/950286Fecal Calprotectin Use in Inflammatory Bowel Disease and Beyond: A Mini-ReviewBashaar Alibrahim0Mohammed I Aljasser1Baljinder Salh2Division of Internal Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi ArabiaDivision of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaGiven the number of inflammatory disorders affecting the gastrointestinal tract directly and indirectly, coupled with the considerable overlap with functional disorders, it is evident that more useful noninvasive diagnostic tests are required to aid with diagnosis. If these tests can also have some utility for individual patient follow-up in terms of disease activity and response to treatment, as well as providing forewarning of disease relapse, it would be extremely useful information for the clinician. One recently described test that may fulfill several of these attributes is based on leakage of a mononuclear cell cytoplasmic protein, calprotectin, along the intestinal tract, which can then be quantified in feces. This has been used to distinguish patients exhibiting symptoms of irritable bowel syndrome from patients with inflammatory bowel disease, with a measure of success greater than with currently used techniques. The present article summarizes the experience with this test used in inflammatory bowel disease, as well as a variety of gastrointestinal disorders.http://dx.doi.org/10.1155/2015/950286 |
| spellingShingle | Bashaar Alibrahim Mohammed I Aljasser Baljinder Salh Fecal Calprotectin Use in Inflammatory Bowel Disease and Beyond: A Mini-Review Canadian Journal of Gastroenterology and Hepatology |
| title | Fecal Calprotectin Use in Inflammatory Bowel Disease and Beyond: A Mini-Review |
| title_full | Fecal Calprotectin Use in Inflammatory Bowel Disease and Beyond: A Mini-Review |
| title_fullStr | Fecal Calprotectin Use in Inflammatory Bowel Disease and Beyond: A Mini-Review |
| title_full_unstemmed | Fecal Calprotectin Use in Inflammatory Bowel Disease and Beyond: A Mini-Review |
| title_short | Fecal Calprotectin Use in Inflammatory Bowel Disease and Beyond: A Mini-Review |
| title_sort | fecal calprotectin use in inflammatory bowel disease and beyond a mini review |
| url | http://dx.doi.org/10.1155/2015/950286 |
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