A thioacetamide-induced hepatic encephalopathy model in C57BL/6 mice: a behavioral and neurochemical study Modelo de encefalopatia hepática induzida por tioacetamida em camundongos C57BL/6: estudo comportamental e neuroquímico

A thioacetamide-induced hepatic encephalopathy model in C57BL/6 mice: a behavioral and neurochemical study Modelo de encefalopatia hepática induzida por tioacetamida em camundongos C57BL/6: estudo comportamental e neuroquímico

OBJECTIVE: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome resulting from liver failure. In the present study, we aimed to standardize an animal model of HE induced by thioacetamide (TAA) in C57BL/6 mice evaluating behavioral symptoms in association with liver damage and alterations in ne...

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Main Authors: Aline Silva de Miranda, David Henrique Rodrigues, Luciene Bruno Vieira, Cristiano Xavier Lima, Milene Alvarenga Rachid, Paula Vieira Teixeira Vidigal, Marcus Vinicius Gomez, Helton José dos Reis, Cristina Guatimosim, Antônio Lúcio Teixeira
Format: Article
Language:English
Published: Thieme Revinter Publicações 2010-08-01
Series:Arquivos de Neuro-Psiquiatria
Subjects:
encefalopatia hepática
tioacetamida
alterações comportamentais
SHIRPA
glutamato
hepatic encephalopathy
thioacetamide
behavioral changes
glutamate
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000400022
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