The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Abstract Metabolic processes and epigenetic reprogramming are intricately interconnected; however, their mechanistic interplay remains unclear. This study elucidates the role of ATP‐citrate lyase (ACLY), an essential enzyme in acetyl‐CoA production that uniquely localizes to the nucleus in oocytes a...

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Main Authors: Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
ACLY
P300
HAT1
early embryo development
histone acetylation
Online Access:https://doi.org/10.1002/advs.202414367
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https://doi.org/10.1002/advs.202414367

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