Improving Ex Vivo Nasal Mucosa Experimental Design for Drug Permeability Assessments: Correcting Mucosal Thickness Interference and Reevaluating Fluorescein Sodium as an Integrity Marker for Chemically Induced Mucosal Injury

Improving Ex Vivo Nasal Mucosa Experimental Design for Drug Permeability Assessments: Correcting Mucosal Thickness Interference and Reevaluating Fluorescein Sodium as an Integrity Marker for Chemically Induced Mucosal Injury

<b>Objectives</b>: Ex vivo nasal mucosa models provide physiologically relevant platforms for evaluating nasal drug permeability; however, their application is often limited by high experimental variability and the absence of standardized methodologies. This study aimed to improve experi...

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Bibliographic Details
Main Authors: Shengnan Zhao, Jieyu Zuo, Marlon C. Mallillin, Ruikun Tang, Michael R. Doschak, Neal M. Davies, Raimar Löbenberg
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceuticals
Subjects:
nasal mucosa
thickness correction
nasal permeability
Franz cell
ex vivo permeation study
fluorescein sodium
Online Access:https://www.mdpi.com/1424-8247/18/6/889
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