Downregulation of the immunoproteasome subunit PSMB8 attenuates sepsis-associated acute kidney injury through the NF-κB pathway

Downregulation of the immunoproteasome subunit PSMB8 attenuates sepsis-associated acute kidney injury through the NF-κB pathway

Sepsis-associated acute kidney injury (S-AKI) is a prevalent and life-threatening complication in hospitalized and critically ill patients. Recent researches indicates that immunoproteasome, especially proteasome 20S subunit beta 8 (PSMB8), is highly associated with various kidney diseases. This stu...

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Bibliographic Details
Main Authors: Min Li, Wenjia Tong, Chao Dai, Guoping Lu, Danqun Jin, Fang Deng
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Immunobiology
Subjects:
Sepsis-induced acute kidney
PSMB8
NF-κB
Inflammation
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0171298524000809
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