Distinct subcellular localization of tau and alpha-synuclein in lewy body disease
Abstract Lewy bodies and neurofibrillary tangles, composed of α-synuclein (α-syn) and tau, respectively, often are found together in the same brain and correlate with worsening cognition. Human postmortem studies show colocalization of α-syn and tau occurs in Lewy bodies, but with limited effort to...
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Main Authors: | D. Luke Fischer, Marissa Menard, Omar Z. Abdelaziz, Nicholas M. Kanaan, Virginia G. Cobbs, Richard E. Kennedy, Geidy E. Serrano, Thomas G. Beach, Laura A. Volpicelli-Daley |
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Format: | Article |
Language: | English |
Published: |
BMC
2025-01-01
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Series: | Acta Neuropathologica Communications |
Subjects: | |
Online Access: | https://doi.org/10.1186/s40478-024-01913-w |
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