Distinct subcellular localization of tau and alpha-synuclein in lewy body disease

Distinct subcellular localization of tau and alpha-synuclein in lewy body disease

Abstract Lewy bodies and neurofibrillary tangles, composed of α-synuclein (α-syn) and tau, respectively, often are found together in the same brain and correlate with worsening cognition. Human postmortem studies show colocalization of α-syn and tau occurs in Lewy bodies, but with limited effort to...

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Main Authors: D. Luke Fischer, Marissa Menard, Omar Z. Abdelaziz, Nicholas M. Kanaan, Virginia G. Cobbs, Richard E. Kennedy, Geidy E. Serrano, Thomas G. Beach, Laura A. Volpicelli-Daley
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Acta Neuropathologica Communications
Subjects:
Tau
Alpha-synuclein
Lewy body
Neurofibrillary tangle
Copathology
Online Access:https://doi.org/10.1186/s40478-024-01913-w
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https://doi.org/10.1186/s40478-024-01913-w

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