Design of anti-depressant phosphodiester amino acidic Keap1-Nrf2 protein-protein interaction inhibitors

Design of anti-depressant phosphodiester amino acidic Keap1-Nrf2 protein-protein interaction inhibitors

Inhibiting the protein-protein interaction (PPI) between Keap1 and Nrf2 is theoretically an effective and safe strategy for activation of Nrf2 pathway to treat major depressive disorder (MDD). In this study, through bioinformatic analysis of the brain tissues and peripheral blood of MDD patients and...

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Bibliographic Details
Main Authors: Yi Sun, Jue Wang, Wenxin Ding, Qingqing Qin, Rui Wang, Ruizhi Yu, Jianyu Yan, Ruilin Hou, Guodong Liu, Xiangming Cai, Zhuo Qu, Wannian Zhang, Jianqiang Yu, Chengguo Xing, Chunlin Zhuang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Redox Biology
Subjects:
Keap1
Nrf2
Protein-protein interaction
Inhibitor
Anti-depressant
Phosphodiester
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001338
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