Preoperative Low-Density Lipoprotein Apheresis for Preventing Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation
Background. Focal segmental glomerulosclerosis (FSGS) often develops rapidly and frequently progresses to renal failure, while the recurrence rate after kidney transplantation is 20–50%. We performed low-density lipoprotein (LDL) apheresis before kidney transplantation in FSGS patients to prevent re...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2018/8926786 |
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| author | Akihito Sannomiya Toru Murakami Ichiro Koyama Kosaku Nitta Ichiro Nakajima Shohei Fuchinoue |
| author_facet | Akihito Sannomiya Toru Murakami Ichiro Koyama Kosaku Nitta Ichiro Nakajima Shohei Fuchinoue |
| author_sort | Akihito Sannomiya |
| collection | DOAJ |
| description | Background. Focal segmental glomerulosclerosis (FSGS) often develops rapidly and frequently progresses to renal failure, while the recurrence rate after kidney transplantation is 20–50%. We performed low-density lipoprotein (LDL) apheresis before kidney transplantation in FSGS patients to prevent recurrence. Methods. Five adult patients with chronic renal failure due to FSGS undergoing living related donor kidney transplantation were investigated retrospectively. LDL apheresis was done 1-2 times before transplantation. Postoperative renal function and recurrence of FSGS were assessed. Results. The patients were two men and three women aged 24 to 41 years. The observation period ranged from 60 days to 22 months. Preoperative LDL apheresis was performed once in one patient and twice in four patients. Blood LDL cholesterol levels were normal before LDL apheresis and remained normal both after LDL apheresis and after kidney transplantation. Additional LDL apheresis was performed once in one patient with mild proteinuria after transplantation. The renal graft survived in all patients and there was no evidence of recurrent FSGS. Conclusions. Although the observation period was short, FSGS did not recur in all 5 patients receiving preoperative LDL apheresis. These results suggest that LDL apheresis can be effective in preventing recurrence of FSGS after kidney transplantation. |
| format | Article |
| id | doaj-art-ebbb738709854e3bb457bc1f58e3c5a4 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-ebbb738709854e3bb457bc1f58e3c5a42025-02-03T05:50:52ZengWileyJournal of Transplantation2090-00072090-00152018-01-01201810.1155/2018/89267868926786Preoperative Low-Density Lipoprotein Apheresis for Preventing Recurrence of Focal Segmental Glomerulosclerosis after Kidney TransplantationAkihito Sannomiya0Toru Murakami1Ichiro Koyama2Kosaku Nitta3Ichiro Nakajima4Shohei Fuchinoue5Department of Surgery, Kidney Center, Tokyo Women’s Medical University, Tokyo, JapanDepartment of Surgery, Kidney Center, Tokyo Women’s Medical University, Tokyo, JapanDepartment of Surgery, Kidney Center, Tokyo Women’s Medical University, Tokyo, JapanDepartment of Medicine, Kidney Center, Tokyo Women’s Medical University, Tokyo, JapanDepartment of Surgery, Kidney Center, Tokyo Women’s Medical University, Tokyo, JapanDepartment of Surgery, Kidney Center, Tokyo Women’s Medical University, Tokyo, JapanBackground. Focal segmental glomerulosclerosis (FSGS) often develops rapidly and frequently progresses to renal failure, while the recurrence rate after kidney transplantation is 20–50%. We performed low-density lipoprotein (LDL) apheresis before kidney transplantation in FSGS patients to prevent recurrence. Methods. Five adult patients with chronic renal failure due to FSGS undergoing living related donor kidney transplantation were investigated retrospectively. LDL apheresis was done 1-2 times before transplantation. Postoperative renal function and recurrence of FSGS were assessed. Results. The patients were two men and three women aged 24 to 41 years. The observation period ranged from 60 days to 22 months. Preoperative LDL apheresis was performed once in one patient and twice in four patients. Blood LDL cholesterol levels were normal before LDL apheresis and remained normal both after LDL apheresis and after kidney transplantation. Additional LDL apheresis was performed once in one patient with mild proteinuria after transplantation. The renal graft survived in all patients and there was no evidence of recurrent FSGS. Conclusions. Although the observation period was short, FSGS did not recur in all 5 patients receiving preoperative LDL apheresis. These results suggest that LDL apheresis can be effective in preventing recurrence of FSGS after kidney transplantation.http://dx.doi.org/10.1155/2018/8926786 |
| spellingShingle | Akihito Sannomiya Toru Murakami Ichiro Koyama Kosaku Nitta Ichiro Nakajima Shohei Fuchinoue Preoperative Low-Density Lipoprotein Apheresis for Preventing Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation Journal of Transplantation |
| title | Preoperative Low-Density Lipoprotein Apheresis for Preventing Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation |
| title_full | Preoperative Low-Density Lipoprotein Apheresis for Preventing Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation |
| title_fullStr | Preoperative Low-Density Lipoprotein Apheresis for Preventing Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation |
| title_full_unstemmed | Preoperative Low-Density Lipoprotein Apheresis for Preventing Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation |
| title_short | Preoperative Low-Density Lipoprotein Apheresis for Preventing Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation |
| title_sort | preoperative low density lipoprotein apheresis for preventing recurrence of focal segmental glomerulosclerosis after kidney transplantation |
| url | http://dx.doi.org/10.1155/2018/8926786 |
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