A broad spectrum Shigella vaccine based on VirG53 – 353 multiepitope region produced in a cell-free system

A broad spectrum Shigella vaccine based on VirG53 – 353 multiepitope region produced in a cell-free system

Abstract Dysentery caused by Shigella species remains a major health threat to children in low- and middle-income countries. There is no vaccine available. The most advanced candidates, i.e., O-polysaccharide (OPS)-based conjugates, have limited coverage—only against the immunizing serotype. Vaccine...

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Main Authors: Girmay Desalegn, Charlotte Abrahamson, K. Ross Turbyfill, Lucy Pill-Pepe, Leslie Bautista, Chitradevi S. Tamilselvi, Dylan Dunn, Neeraj Kapoor, Barbara Sullinger, Matheo Herrera, Edwin V. Oaks, Jeff Fairman, Marcela F. Pasetti
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01064-6
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https://doi.org/10.1038/s41541-025-01064-6

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