Exploring the value of a well-established conditioned pain modulation paradigm in women: a Translational Research in Pelvic Pain (TRiPP) study

Exploring the value of a well-established conditioned pain modulation paradigm in women: a Translational Research in Pelvic Pain (TRiPP) study

BackgroundConditioned pain modulation (CPM) is considered a human proxy for descending inhibitory pain pathways. However, there is wide variation in the CPM response described in the literature and ongoing debate about its utility. MethodsHere we explored CPM in women with (n = 59) and without (n = ...

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Main Authors: Lysia Demetriou, Danielle Perro, Lydia Coxon, Michal Krassowski, Claire E. Lunde, Joana Ferreira-Gomes, Ana Charrua, Pedro Abreu-Mendes, Lars Arendt-Nielsen, Qasim Aziz, Judy Birch, Kurtis Garbutt, Andrew Horne, Anja Hoffman, Lone Hummelshoj, Jane Meijlink, Maik Obendorf, Esther Pogatzki-Zahn, Naoko Sasamoto, Kathryn Terry, Rolf-Detlef Treede, Allison Vitonis, Jan Vollert, Nilufer Rahmioglu, Christian M. Becker, Francisco Cruz, Stacey A. Missmer, Krina Zondervan, Christine B. Sieberg, Jens Nagel, Katy Vincent
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pain Research
Subjects:
conditioned pain modulation
chronic pelvic pain
quantitative sensory testing
women's health
pain characteristics
Online Access:https://www.frontiersin.org/articles/10.3389/fpain.2025.1439563/full
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