The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids
Background. Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases. The presented study describes the influence...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/7352637 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566308982489088 |
|---|---|
| author | Drahomira Holmannova Lenka Borska Ctirad Andrys Pavel Borsky Jan Kremlacek Kvetoslava Hamakova Vit Rehacek Andrea Malkova Tereza Svadlakova Vladimir Palicka Jan Krejsek Zdenek Fiala |
| author_facet | Drahomira Holmannova Lenka Borska Ctirad Andrys Pavel Borsky Jan Kremlacek Kvetoslava Hamakova Vit Rehacek Andrea Malkova Tereza Svadlakova Vladimir Palicka Jan Krejsek Zdenek Fiala |
| author_sort | Drahomira Holmannova |
| collection | DOAJ |
| description | Background. Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases. The presented study describes the influence of psoriasis and MetS on the serum levels of markers of systemic inflammation (calprotectin and ANGPTL8) and markers of oxidative damage to nucleic acids. The applicability of serum levels of calprotectin and ANGPTL8 for monitoring of the activity of psoriasis (diagnostic markers) is also evaluated. Methods. Clinical examination (PASI score, MetS), enzyme-linked immunosorbent assay (ELISA), and Enzyme Immunoassay (EIA). Serum calprotectin, ANGPTL8, 8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine. Results and Conclusions. The psoriasis significantly increased the serum level of calprotectin and the serum level of oxidative damage to nucleic acids, however not the serum level of ANGPTL8. The presence of MetS did not significantly affect the serum levels of calprotectin, ANGPTL8, and oxidative damage to nucleic acids in either psoriasis patients or controls. It seems that the serum level of calprotectin (but not the serum level of ANGPTL8) could be used as a biomarker for monitoring the activity of psoriasis. |
| format | Article |
| id | doaj-art-eb9a966c21b64696b3575619d1a15c10 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-eb9a966c21b64696b3575619d1a15c102025-02-03T01:04:38ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/73526377352637The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic AcidsDrahomira Holmannova0Lenka Borska1Ctirad Andrys2Pavel Borsky3Jan Kremlacek4Kvetoslava Hamakova5Vit Rehacek6Andrea Malkova7Tereza Svadlakova8Vladimir Palicka9Jan Krejsek10Zdenek Fiala11Institute of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Czech RepublicInstitute of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University, Czech RepublicInstitute of Clinical Immunology and Allergology, University Hospital and Faculty of Medicine in Hradec Kralove, Charles University, Czech RepublicInstitute of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Czech RepublicInstitute of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University, Czech RepublicClinic of Dermatology and Venereology, University Hospital Hradec Kralove, Czech RepublicTransfusion Center, University Hospital, Hradec Kralove 500 03, Czech RepublicInstitute of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Czech RepublicInstitute of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Czech RepublicInstitute of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University, Czech RepublicInstitute of Clinical Immunology and Allergology, University Hospital and Faculty of Medicine in Hradec Kralove, Charles University, Czech RepublicInstitute of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Czech RepublicBackground. Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases. The presented study describes the influence of psoriasis and MetS on the serum levels of markers of systemic inflammation (calprotectin and ANGPTL8) and markers of oxidative damage to nucleic acids. The applicability of serum levels of calprotectin and ANGPTL8 for monitoring of the activity of psoriasis (diagnostic markers) is also evaluated. Methods. Clinical examination (PASI score, MetS), enzyme-linked immunosorbent assay (ELISA), and Enzyme Immunoassay (EIA). Serum calprotectin, ANGPTL8, 8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine. Results and Conclusions. The psoriasis significantly increased the serum level of calprotectin and the serum level of oxidative damage to nucleic acids, however not the serum level of ANGPTL8. The presence of MetS did not significantly affect the serum levels of calprotectin, ANGPTL8, and oxidative damage to nucleic acids in either psoriasis patients or controls. It seems that the serum level of calprotectin (but not the serum level of ANGPTL8) could be used as a biomarker for monitoring the activity of psoriasis.http://dx.doi.org/10.1155/2020/7352637 |
| spellingShingle | Drahomira Holmannova Lenka Borska Ctirad Andrys Pavel Borsky Jan Kremlacek Kvetoslava Hamakova Vit Rehacek Andrea Malkova Tereza Svadlakova Vladimir Palicka Jan Krejsek Zdenek Fiala The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids Journal of Immunology Research |
| title | The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids |
| title_full | The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids |
| title_fullStr | The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids |
| title_full_unstemmed | The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids |
| title_short | The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids |
| title_sort | impact of psoriasis and metabolic syndrome on the systemic inflammation and oxidative damage to nucleic acids |
| url | http://dx.doi.org/10.1155/2020/7352637 |
| work_keys_str_mv | AT drahomiraholmannova theimpactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT lenkaborska theimpactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT ctiradandrys theimpactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT pavelborsky theimpactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT jankremlacek theimpactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT kvetoslavahamakova theimpactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT vitrehacek theimpactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT andreamalkova theimpactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT terezasvadlakova theimpactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT vladimirpalicka theimpactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT jankrejsek theimpactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT zdenekfiala theimpactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT drahomiraholmannova impactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT lenkaborska impactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT ctiradandrys impactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT pavelborsky impactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT jankremlacek impactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT kvetoslavahamakova impactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT vitrehacek impactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT andreamalkova impactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT terezasvadlakova impactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT vladimirpalicka impactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT jankrejsek impactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids AT zdenekfiala impactofpsoriasisandmetabolicsyndromeonthesystemicinflammationandoxidativedamagetonucleicacids |