Lateral flow assay as radiological prognosis factor of pulmonary cryptococcosis: a single center retrospective study in China
BackgroundLateral flow assay (LFA) has demonstrated high sensitivity and specificity for diagnosing cryptococcosis. However, its role in predicting therapeutic efficacy for pulmonary cryptococcosis (PC) remains underexplored.MethodsWe conducted a retrospective analysis of HIV-negative patients with...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1497082/full |
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| author | Jiejun Shi Jianhua Chen Qianjiang Ding Guoqing Qian Zeqin Zhang Qifa Song |
| author_facet | Jiejun Shi Jianhua Chen Qianjiang Ding Guoqing Qian Zeqin Zhang Qifa Song |
| author_sort | Jiejun Shi |
| collection | DOAJ |
| description | BackgroundLateral flow assay (LFA) has demonstrated high sensitivity and specificity for diagnosing cryptococcosis. However, its role in predicting therapeutic efficacy for pulmonary cryptococcosis (PC) remains underexplored.MethodsWe conducted a retrospective analysis of HIV-negative patients with PC to describe the clinical profile and identify potential predictors of radiological prognosis.ResultsAll the 168 participants received antifungal therapy with a triazole agent. Of these, 84.5% experienced partial or complete absorption of pulmonary lesions. The results of the gamma test, chi-square trend test, and ordinal logistic regression all indicated that both baseline LFA and changes in LFA after treatment were significant predictors of imaging prognosis. The degree of radiological improvement was inversely associated with the baseline LFA positive grade(P for linear-by-linear association: 0.011, Spearman correlation coefficient = -0.17; γ= -0.368, P = 0.045). Patients with a decrease in LFA after therapy had significantly better radiological outcomes compared to those with equal or increased LFA(linear-by-linear association, P = 0.014, Spearman correlation coefficient = 0.188; γ = 0.371, P = 0.012). Additionally, favorable outcomes were more likely in patients with lesions confined to the right lung.ConclusionsLFA shows potential of monitoring radiological outcomes in pulmonary cryptococcosis. |
| format | Article |
| id | doaj-art-eb8d1f4ec1244575ac6ce801bd0a6e5b |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-eb8d1f4ec1244575ac6ce801bd0a6e5b2025-01-21T05:43:19ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-01-011410.3389/fcimb.2024.14970821497082Lateral flow assay as radiological prognosis factor of pulmonary cryptococcosis: a single center retrospective study in ChinaJiejun Shi0Jianhua Chen1Qianjiang Ding2Guoqing Qian3Zeqin Zhang4Qifa Song5Department of Infectious Diseases, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaMedical Data Center, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaBackgroundLateral flow assay (LFA) has demonstrated high sensitivity and specificity for diagnosing cryptococcosis. However, its role in predicting therapeutic efficacy for pulmonary cryptococcosis (PC) remains underexplored.MethodsWe conducted a retrospective analysis of HIV-negative patients with PC to describe the clinical profile and identify potential predictors of radiological prognosis.ResultsAll the 168 participants received antifungal therapy with a triazole agent. Of these, 84.5% experienced partial or complete absorption of pulmonary lesions. The results of the gamma test, chi-square trend test, and ordinal logistic regression all indicated that both baseline LFA and changes in LFA after treatment were significant predictors of imaging prognosis. The degree of radiological improvement was inversely associated with the baseline LFA positive grade(P for linear-by-linear association: 0.011, Spearman correlation coefficient = -0.17; γ= -0.368, P = 0.045). Patients with a decrease in LFA after therapy had significantly better radiological outcomes compared to those with equal or increased LFA(linear-by-linear association, P = 0.014, Spearman correlation coefficient = 0.188; γ = 0.371, P = 0.012). Additionally, favorable outcomes were more likely in patients with lesions confined to the right lung.ConclusionsLFA shows potential of monitoring radiological outcomes in pulmonary cryptococcosis.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1497082/fullpulmonary cryptococcosislateral flow assaytherapeutic efficacyradiological prognosislesion distributionHIV-negative |
| spellingShingle | Jiejun Shi Jianhua Chen Qianjiang Ding Guoqing Qian Zeqin Zhang Qifa Song Lateral flow assay as radiological prognosis factor of pulmonary cryptococcosis: a single center retrospective study in China Frontiers in Cellular and Infection Microbiology pulmonary cryptococcosis lateral flow assay therapeutic efficacy radiological prognosis lesion distribution HIV-negative |
| title | Lateral flow assay as radiological prognosis factor of pulmonary cryptococcosis: a single center retrospective study in China |
| title_full | Lateral flow assay as radiological prognosis factor of pulmonary cryptococcosis: a single center retrospective study in China |
| title_fullStr | Lateral flow assay as radiological prognosis factor of pulmonary cryptococcosis: a single center retrospective study in China |
| title_full_unstemmed | Lateral flow assay as radiological prognosis factor of pulmonary cryptococcosis: a single center retrospective study in China |
| title_short | Lateral flow assay as radiological prognosis factor of pulmonary cryptococcosis: a single center retrospective study in China |
| title_sort | lateral flow assay as radiological prognosis factor of pulmonary cryptococcosis a single center retrospective study in china |
| topic | pulmonary cryptococcosis lateral flow assay therapeutic efficacy radiological prognosis lesion distribution HIV-negative |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1497082/full |
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