Meta-analysis of Germline Whole-exome Sequencing in 1435 Cases of Testicular Germ Cell Tumour to Evaluate Disruptive Mutations Under Dominant, Recessive, and X-linked Inheritance Models

Meta-analysis of Germline Whole-exome Sequencing in 1435 Cases of Testicular Germ Cell Tumour to Evaluate Disruptive Mutations Under Dominant, Recessive, and X-linked Inheritance Models

Background and objective: Testicular germ cell tumour (TGCT) is the most common cancer in young men, and over half of its high estimated heritability is unexplained. Our objective was to identify rare pathogenic germline variation driving TGCT susceptibility. Methods: This study is a case-control me...

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Main Authors: Zeid Kuzbari, Charlie F. Rowlands, Isaac Wade, Alice Garrett, Chey Loveday, Subin Choi, Beth Torr, Kevin Litchfield, Alison Reid, Robert Huddart, Peter Broderick, Richard S. Houlston, Clare Turnbull
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:European Urology Open Science
Subjects:
Cancer susceptibility genes
Gene association testing
Germ cell tumour
Germline mutations
Meta-analysis
Testicular cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2666168325000540
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