Tumor-intrinsic TTLL12 drives resistance to cancer immunotherapy via modulating myeloid-derived suppressor cells

Background The majority of patients treated with immunotherapy as a standalone therapy experience little to no benefits. Tubulin tyrosine ligase 12 (TTLL12), as a member of the tubulin tyrosine ligase protein family, is associated with the prognosis of patients with cancer and implicated in regulati...

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Main Authors: Chong Chen, Xin-xin Huang, Ping Lan, Dong-Wen Chen, Yi-Kan Cheng, Pei-Si Li, Xiao-Jian Wu, Jia-Hui Long, Zhizhong Xiong, Shu-Biao Ye
Format: Article
Language:English
Published: BMJ Publishing Group 2025-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/6/e010873.full
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