Synthesis of piperazine-based benzimidazole derivatives as potent urease inhibitors and molecular docking studies

Synthesis of piperazine-based benzimidazole derivatives as potent urease inhibitors and molecular docking studies

Abstract The development of new bioactive compounds is important for progress in therapeutic research. In the present study, we describe the multistep synthetic approach to develop a library of novel benzimidazole analogs incorporating piperazine rings in order to increase their biological activity....

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Main Authors: Delaram Shahriarynejad, Navid Dastyafteh, Fouzia Naz, Meysam Talebi, Sajedeh Safapoor, Seyedeh Niloufar Ghafouri, Homa Azizian, Maryam Mohammadi-Khanaposhtani, Bagher Larijani, Mehdi Asadi, Massoud Amanlou, Mohammad Mahdavi, Khalid Mohammed Khan
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Benzimidazole
Piperazine
Urease inhibition
Docking study
Online Access:https://doi.org/10.1038/s41598-025-14723-4
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https://doi.org/10.1038/s41598-025-14723-4

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