Coronary Artery Disease–Based Polygenic Risk Score in Early-Onset Acute Myocardial Infarction Subtypes

Coronary Artery Disease–Based Polygenic Risk Score in Early-Onset Acute Myocardial Infarction Subtypes

Background: The coronary artery disease–based polygenic risk score (PRS-CAD) estimates risk of acute myocardial infarction (AMI), but its performance across AMI subtypes in younger individuals, especially women, remains uncertain. Objectives: The authors assessed PRS-CAD's performance in AMI su...

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Main Authors: Weilai Dong, MD, PhD, Yuan Lu, ScD, Shu-Xia Li, PhD, Mitsuaki Sawano, MD, PhD, Cesar Caraballo, MD, Yuntian Liu, MPH, Amit Khera, MD, MSc, Anthony Philippakis, MD, PhD, Rachel Dreyer, PhD, Judith Lichtman, PhD, MPH, Gail D'Onofrio, MD, MS, Erica S. Spatz, MD, MHS, David Herrington, MD, MHS, Wendy S. Post, MD, MS, Stephen S. Rich, PhD, Jerome I. Rotter, MD, Harlan M. Krumholz, MD, SM
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:JACC: Advances
Subjects:
acute myocardial infarction
polygenic risk score
subtypes
Online Access:http://www.sciencedirect.com/science/article/pii/S2772963X25004181
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