Cytochrome P450 monooxygenase-mediated eicosanoid pathway: A potential mechanistic linkage between dietary fatty acid consumption and colon cancer risk
Human consumption of linoleic acid (LA, 18:2ω-6, abundant in vegetable oils) is very high. Animal experiments showed that excessive LA intake increased azoxymethane-induced colon tumorigenesis, however, the impact of excessive LA on colon cancer in human is not conclusive, making it difficult to mak...
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Tsinghua University Press
2019-12-01
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| Series: | Food Science and Human Wellness |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453019301211 |
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| author | Weicang Wang Jianan Zhang Guodong Zhang |
| author_facet | Weicang Wang Jianan Zhang Guodong Zhang |
| author_sort | Weicang Wang |
| collection | DOAJ |
| description | Human consumption of linoleic acid (LA, 18:2ω-6, abundant in vegetable oils) is very high. Animal experiments showed that excessive LA intake increased azoxymethane-induced colon tumorigenesis, however, the impact of excessive LA on colon cancer in human is not conclusive, making it difficult to make dietary recommendations for optimal intake of LA. Understanding the molecular mechanisms of LA on colon tumorigenesis could help to clarify its health effect, and facilitate development of mechanism-based strategies for preventing colon cancer. Recent studies show that the previously unappreciated cytochrome P450 monooxygenase-mediated eicosanoid pathway is upregulated in colon cancer and plays critical roles in its pathogenesis, and could contribute to the effects of dietary LA, as well as ω-3 fatty acids, on colon tumorigenesis. In this review, we will discuss recent studies about the roles of cytochrome P450 monooxygenases in fatty acid metabolism and its roles in colonic inflammation and colon cancer, and how this information could help us to clarify the health impacts of dietary fatty acids. Keywords: Linoleic acid, Polyunsaturated fatty acids, ω-3 Fatty acids, Colon cancer, Colonic inflammation, Cytochrome P450, Eicosanoids |
| format | Article |
| id | doaj-art-eb0a3ccc4f8c43269a05603a7e836043 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-eb0a3ccc4f8c43269a05603a7e8360432025-02-03T04:07:57ZengTsinghua University PressFood Science and Human Wellness2213-45302019-12-0184337343Cytochrome P450 monooxygenase-mediated eicosanoid pathway: A potential mechanistic linkage between dietary fatty acid consumption and colon cancer riskWeicang Wang0Jianan Zhang1Guodong Zhang2Department of Food Science, University of Massachusetts-Amherst, Amherst, MA, 01003, USADepartment of Food Science, University of Massachusetts-Amherst, Amherst, MA, 01003, USADepartment of Food Science, University of Massachusetts-Amherst, Amherst, MA, 01003, USA; Molecular and Cellular Biology Program, University of Massachusetts-Amherst, Amherst, MA, 01003, USA; Corresponding author at: Department of Food Science, University of Massachusetts-Amherst, Amherst, MA, 01003, USA.Human consumption of linoleic acid (LA, 18:2ω-6, abundant in vegetable oils) is very high. Animal experiments showed that excessive LA intake increased azoxymethane-induced colon tumorigenesis, however, the impact of excessive LA on colon cancer in human is not conclusive, making it difficult to make dietary recommendations for optimal intake of LA. Understanding the molecular mechanisms of LA on colon tumorigenesis could help to clarify its health effect, and facilitate development of mechanism-based strategies for preventing colon cancer. Recent studies show that the previously unappreciated cytochrome P450 monooxygenase-mediated eicosanoid pathway is upregulated in colon cancer and plays critical roles in its pathogenesis, and could contribute to the effects of dietary LA, as well as ω-3 fatty acids, on colon tumorigenesis. In this review, we will discuss recent studies about the roles of cytochrome P450 monooxygenases in fatty acid metabolism and its roles in colonic inflammation and colon cancer, and how this information could help us to clarify the health impacts of dietary fatty acids. Keywords: Linoleic acid, Polyunsaturated fatty acids, ω-3 Fatty acids, Colon cancer, Colonic inflammation, Cytochrome P450, Eicosanoidshttp://www.sciencedirect.com/science/article/pii/S2213453019301211 |
| spellingShingle | Weicang Wang Jianan Zhang Guodong Zhang Cytochrome P450 monooxygenase-mediated eicosanoid pathway: A potential mechanistic linkage between dietary fatty acid consumption and colon cancer risk Food Science and Human Wellness |
| title | Cytochrome P450 monooxygenase-mediated eicosanoid pathway: A potential mechanistic linkage between dietary fatty acid consumption and colon cancer risk |
| title_full | Cytochrome P450 monooxygenase-mediated eicosanoid pathway: A potential mechanistic linkage between dietary fatty acid consumption and colon cancer risk |
| title_fullStr | Cytochrome P450 monooxygenase-mediated eicosanoid pathway: A potential mechanistic linkage between dietary fatty acid consumption and colon cancer risk |
| title_full_unstemmed | Cytochrome P450 monooxygenase-mediated eicosanoid pathway: A potential mechanistic linkage between dietary fatty acid consumption and colon cancer risk |
| title_short | Cytochrome P450 monooxygenase-mediated eicosanoid pathway: A potential mechanistic linkage between dietary fatty acid consumption and colon cancer risk |
| title_sort | cytochrome p450 monooxygenase mediated eicosanoid pathway a potential mechanistic linkage between dietary fatty acid consumption and colon cancer risk |
| url | http://www.sciencedirect.com/science/article/pii/S2213453019301211 |
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