Transcriptional Intermediary Factor 1γ–Induced Irisin in Skeletal Muscle Attenuates Renal Fibrosis in Diabetic Nephropathy

Transcriptional Intermediary Factor 1γ–Induced Irisin in Skeletal Muscle Attenuates Renal Fibrosis in Diabetic Nephropathy

ABSTRACT Background Transcriptional intermediary factor 1γ (TIF1γ) is a negative regulator of TGF‐β1 signalling and has been associated with patient survival in renal cell carcinoma. However, its role in diabetes mellitus (DM), particularly in diabetic nephropathy (DN), remains unclear. DN is the le...

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Main Authors: Jin Hyun Kim, Seunghye Lee, Hani Jang, Sehyun Jung, Myeong Hee Jung, Jeong Won Yun, Haejin Jeon, Hyun‐Jung Kim, Se‐Ho Chang, Eun Ju Lee, Hyo‐Soo Kim
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
chronic kidney disease
diabetic nephropathy
fibrosis
irisin
muscle‐kidney crosstalk
transcriptional intermediary factor 1γ
Online Access:https://doi.org/10.1002/jcsm.13810
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https://doi.org/10.1002/jcsm.13810

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