Highly immunogenic DNA/LION nanocarrier vaccine potently activates lymph nodes inducing long-lasting immunity in macaques

Highly immunogenic DNA/LION nanocarrier vaccine potently activates lymph nodes inducing long-lasting immunity in macaques

Summary: A SARS-CoV-2 spike DNA vaccine formulated with a cationic nanoparticle emulsion (LION) was tested in Rhesus macaques. It induced robust, long-lasting (>2 years) cellular and humoral immunity, including increased neutralization breadth. T cell responses were predominantly CD8+, in contras...

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Main Authors: Sevasti Karaliota, Maha Moussa, Margherita Rosati, Santhi Devasundaram, Soumya Sengupta, Katherine C. Goldfarbmuren, Robert Burns, Jenifer Bear, Dimitris Stellas, Elizabeth A. Urban, Claire Deleage, Amit P. Khandhar, Jesse Erasmus, Peter Berglund, Steven G. Reed, George N. Pavlakis, Barbara K. Felber
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Immunology
Immune response
Biotechnology
Nanotechnology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225004936
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http://www.sciencedirect.com/science/article/pii/S2589004225004936

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