Synthesis and Antimicrobial Evaluation of a New Series of N-1,3-Benzothiazol-2-ylbenzamides
Enterococcus faecalis is a Gram-positive commensal inhabitant of the intestinal tract of humans, animals, and insects. However, it is also an opportunistic pathogen and has emerged as a leading cause of hospital-acquired extraintestinal infections. Fluoroquinolones have been frequently used to treat...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/181758 |
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| author | Domenico Armenise Alessia Carocci Alessia Catalano Marilena Muraglia Ivana Defrenza Nicolino De Laurentis Antonio Rosato Filomena Corbo Carlo Franchini |
| author_facet | Domenico Armenise Alessia Carocci Alessia Catalano Marilena Muraglia Ivana Defrenza Nicolino De Laurentis Antonio Rosato Filomena Corbo Carlo Franchini |
| author_sort | Domenico Armenise |
| collection | DOAJ |
| description | Enterococcus faecalis is a Gram-positive commensal inhabitant of the intestinal tract of humans, animals, and insects. However, it is also an opportunistic pathogen and has emerged as a leading cause of hospital-acquired extraintestinal infections. Fluoroquinolones have been frequently used to treat E. faecalis infections, and the emergence of fluoroquinolone-resistant E. faecalis strains has recently been reported in several countries. Thus, the identifications of new antibiotics specifically directed to E. faecalis may be envisaged. In this paper, a new series of N-1,3-benzothiazol-2-ylbenzamides have been designed, synthesized, and evaluated for their in vitro antimicrobial activities. Among the tested compounds, 3i was active against E. faecalis. |
| format | Article |
| id | doaj-art-eade0df0700940d79c854d0d94348799 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-eade0df0700940d79c854d0d943487992025-02-03T05:45:26ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/181758181758Synthesis and Antimicrobial Evaluation of a New Series of N-1,3-Benzothiazol-2-ylbenzamidesDomenico Armenise0Alessia Carocci1Alessia Catalano2Marilena Muraglia3Ivana Defrenza4Nicolino De Laurentis5Antonio Rosato6Filomena Corbo7Carlo Franchini8Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro,” Via E. Orabona 4, 70125 Bari, ItalyDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro,” Via E. Orabona 4, 70125 Bari, ItalyDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro,” Via E. Orabona 4, 70125 Bari, ItalyDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro,” Via E. Orabona 4, 70125 Bari, ItalyDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro,” Via E. Orabona 4, 70125 Bari, ItalyDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro,” Via E. Orabona 4, 70125 Bari, ItalyDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro,” Via E. Orabona 4, 70125 Bari, ItalyDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro,” Via E. Orabona 4, 70125 Bari, ItalyDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro,” Via E. Orabona 4, 70125 Bari, ItalyEnterococcus faecalis is a Gram-positive commensal inhabitant of the intestinal tract of humans, animals, and insects. However, it is also an opportunistic pathogen and has emerged as a leading cause of hospital-acquired extraintestinal infections. Fluoroquinolones have been frequently used to treat E. faecalis infections, and the emergence of fluoroquinolone-resistant E. faecalis strains has recently been reported in several countries. Thus, the identifications of new antibiotics specifically directed to E. faecalis may be envisaged. In this paper, a new series of N-1,3-benzothiazol-2-ylbenzamides have been designed, synthesized, and evaluated for their in vitro antimicrobial activities. Among the tested compounds, 3i was active against E. faecalis.http://dx.doi.org/10.1155/2013/181758 |
| spellingShingle | Domenico Armenise Alessia Carocci Alessia Catalano Marilena Muraglia Ivana Defrenza Nicolino De Laurentis Antonio Rosato Filomena Corbo Carlo Franchini Synthesis and Antimicrobial Evaluation of a New Series of N-1,3-Benzothiazol-2-ylbenzamides Journal of Chemistry |
| title | Synthesis and Antimicrobial Evaluation of a New Series of N-1,3-Benzothiazol-2-ylbenzamides |
| title_full | Synthesis and Antimicrobial Evaluation of a New Series of N-1,3-Benzothiazol-2-ylbenzamides |
| title_fullStr | Synthesis and Antimicrobial Evaluation of a New Series of N-1,3-Benzothiazol-2-ylbenzamides |
| title_full_unstemmed | Synthesis and Antimicrobial Evaluation of a New Series of N-1,3-Benzothiazol-2-ylbenzamides |
| title_short | Synthesis and Antimicrobial Evaluation of a New Series of N-1,3-Benzothiazol-2-ylbenzamides |
| title_sort | synthesis and antimicrobial evaluation of a new series of n 1 3 benzothiazol 2 ylbenzamides |
| url | http://dx.doi.org/10.1155/2013/181758 |
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