The changing demographics and severity in hospitalized patients across COVID-19 variants: A national cohort study
Abstract Introduction: The respiratory syndrome coronavirus (SARS-CoV-2) has undergone genetic evolution and led to variants of concern that vary in transmissibility and clinical severity. Methods: This retrospective cohort analysis studied 232,364 hospitalized COVID-19-positive patients in the...
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Cambridge University Press
2025-01-01
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| Series: | Journal of Clinical and Translational Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S205986612401166X/type/journal_article |
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| author | Priyanka Parajuli Lara A.C. Phipps Roy Sabo Rasha Alsaadawi Amanda Robinson Evan French Richard K. Sterling N3C. consortium |
| author_facet | Priyanka Parajuli Lara A.C. Phipps Roy Sabo Rasha Alsaadawi Amanda Robinson Evan French Richard K. Sterling N3C. consortium |
| author_sort | Priyanka Parajuli |
| collection | DOAJ |
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Abstract
Introduction:
The respiratory syndrome coronavirus (SARS-CoV-2) has undergone genetic evolution and led to variants of concern that vary in transmissibility and clinical severity.
Methods:
This retrospective cohort analysis studied 232,364 hospitalized COVID-19-positive patients in the National COVID Cohort Collaborative [April 27, 2020 and June 25, 2022]. The primary outcomes were to compare demographics and need for mechanical ventilation and 30-day mortality across variants including Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529).
Results:
The severity of SARS-CoV-2 decreased in the omicron-subsequent wave with decreased utilization of mechanical ventilation and decreased 30-day mortality among patients with comorbidities like diabetes mellitus, obesity, and liver disease. Although with each subsequent wave, the sex distribution remained equal and constant, there was an increase in rates of diabetes, liver disease, and respiratory disease amongst patients hospitalized with COVID-19 over the COVID waves despite the decreasing 30-day mortality and mechanical ventilation.
Conclusions:
Despite changes in demographics over time, more recent COVID waves were associated with decreasing severity and mortality. These observations will help guide specific and effective resource allocation and patient care.
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| format | Article |
| id | doaj-art-ead75a4a46894fa29083a5f82ae8b5c9 |
| institution | Kabale University |
| issn | 2059-8661 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj-art-ead75a4a46894fa29083a5f82ae8b5c92025-01-23T08:44:17ZengCambridge University PressJournal of Clinical and Translational Science2059-86612025-01-01910.1017/cts.2024.1166The changing demographics and severity in hospitalized patients across COVID-19 variants: A national cohort studyPriyanka Parajuli0https://orcid.org/0000-0002-3261-2330Lara A.C. Phipps1Roy Sabo2https://orcid.org/0000-0001-9159-4876Rasha Alsaadawi3Amanda Robinson4Evan French5Richard K. Sterling6https://orcid.org/0000-0002-8637-2475N3C. consortiumDepartment of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USAUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USAC. Kenneth and Dianne Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA, USA Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, USAC. Kenneth and Dianne Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA, USA Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, USAC. Kenneth and Dianne Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA, USAC. Kenneth and Dianne Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA, USADepartment of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA C. Kenneth and Dianne Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA, USA Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, USA Division of Gastroenterology, Hepatology, and Nutrition, Richmond, VA, USA Division of Infectious Disease, Virginia Commonwealth University, Richmond, VA, USA Abstract Introduction: The respiratory syndrome coronavirus (SARS-CoV-2) has undergone genetic evolution and led to variants of concern that vary in transmissibility and clinical severity. Methods: This retrospective cohort analysis studied 232,364 hospitalized COVID-19-positive patients in the National COVID Cohort Collaborative [April 27, 2020 and June 25, 2022]. The primary outcomes were to compare demographics and need for mechanical ventilation and 30-day mortality across variants including Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529). Results: The severity of SARS-CoV-2 decreased in the omicron-subsequent wave with decreased utilization of mechanical ventilation and decreased 30-day mortality among patients with comorbidities like diabetes mellitus, obesity, and liver disease. Although with each subsequent wave, the sex distribution remained equal and constant, there was an increase in rates of diabetes, liver disease, and respiratory disease amongst patients hospitalized with COVID-19 over the COVID waves despite the decreasing 30-day mortality and mechanical ventilation. Conclusions: Despite changes in demographics over time, more recent COVID waves were associated with decreasing severity and mortality. These observations will help guide specific and effective resource allocation and patient care. https://www.cambridge.org/core/product/identifier/S205986612401166X/type/journal_articleCOVID-19 variantsdemographicssurvivalcomorbiditiesmechanical ventilation |
| spellingShingle | Priyanka Parajuli Lara A.C. Phipps Roy Sabo Rasha Alsaadawi Amanda Robinson Evan French Richard K. Sterling N3C. consortium The changing demographics and severity in hospitalized patients across COVID-19 variants: A national cohort study Journal of Clinical and Translational Science COVID-19 variants demographics survival comorbidities mechanical ventilation |
| title | The changing demographics and severity in hospitalized patients across COVID-19 variants: A national cohort study |
| title_full | The changing demographics and severity in hospitalized patients across COVID-19 variants: A national cohort study |
| title_fullStr | The changing demographics and severity in hospitalized patients across COVID-19 variants: A national cohort study |
| title_full_unstemmed | The changing demographics and severity in hospitalized patients across COVID-19 variants: A national cohort study |
| title_short | The changing demographics and severity in hospitalized patients across COVID-19 variants: A national cohort study |
| title_sort | changing demographics and severity in hospitalized patients across covid 19 variants a national cohort study |
| topic | COVID-19 variants demographics survival comorbidities mechanical ventilation |
| url | https://www.cambridge.org/core/product/identifier/S205986612401166X/type/journal_article |
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