Structural characteristics, functions, and counteracting strategies of biofilms in Staphylococcus aureus
Background: Staphylococcus aureus (S. aureus) is a prevalent pathogen associated with a wide range of infections, exhibiting significant antibiotic resistance and posing therapeutic challenges in clinical settings. The formation of biofilms contributes to the emergence of resistant strains, further...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Computational and Structural Biotechnology Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037025000157 |
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| author | Yanze Xia Zhenghui Hu Qiyuan Jin Qi Chen Chenhao Zhao Rui Qiang Zonggang Xie Liubing Li Haifang Zhang |
| author_facet | Yanze Xia Zhenghui Hu Qiyuan Jin Qi Chen Chenhao Zhao Rui Qiang Zonggang Xie Liubing Li Haifang Zhang |
| author_sort | Yanze Xia |
| collection | DOAJ |
| description | Background: Staphylococcus aureus (S. aureus) is a prevalent pathogen associated with a wide range of infections, exhibiting significant antibiotic resistance and posing therapeutic challenges in clinical settings. The formation of biofilms contributes to the emergence of resistant strains, further diminishing the efficacy of antibiotics. This, in turn, leads to chronic and recurrent infections, ultimately increasing the healthcare burden. Consequently, preventing and eliminating biofilms has become a critical focus in clinical management and research. Aim of review: This review systematically examines the mechanisms underlying biofilm formation in S. aureus and its contribution to antibiotic resistance, emphasizing the essential roles biofilms play in maintaining structural integrity and enhancing resistance. It also analyses the protective mechanisms that fortify S. aureus biofilms against antimicrobial treatments. Furthermore, the review provides a comprehensive overview of recent therapeutic innovations, including enzymatic therapy, nanotechnology, gene editing, and phage therapy. Key scientific concepts of review: Emerging therapeutic strategies present novel approaches to combat S. aureus biofilm-associated infections through various mechanisms. This review discusses recent advancements in these therapies, their practical challenges in clinical application, and provides an in-depth analysis of each strategy’s mechanisms and therapeutic potential. By mapping future research directions, this review aims to refine anti-biofilm strategies to control infection progression and effectively mitigate recurrence. |
| format | Article |
| id | doaj-art-ead5f18b4e0847e0ba7540bafd1762a3 |
| institution | Kabale University |
| issn | 2001-0370 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj-art-ead5f18b4e0847e0ba7540bafd1762a32025-01-28T04:14:33ZengElsevierComputational and Structural Biotechnology Journal2001-03702025-01-0127488500Structural characteristics, functions, and counteracting strategies of biofilms in Staphylococcus aureusYanze Xia0Zhenghui Hu1Qiyuan Jin2Qi Chen3Chenhao Zhao4Rui Qiang5Zonggang Xie6Liubing Li7Haifang Zhang8Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China; Correspondence to: Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; MOE Key Laboratory of Geriatric Diseases and Immunology, Soochow University, Suzhou, China; Correspondence to: Department of Clinical Laboratory, The Second AffiliatedHospital of Soochow University, Suzhou 215004, China.Background: Staphylococcus aureus (S. aureus) is a prevalent pathogen associated with a wide range of infections, exhibiting significant antibiotic resistance and posing therapeutic challenges in clinical settings. The formation of biofilms contributes to the emergence of resistant strains, further diminishing the efficacy of antibiotics. This, in turn, leads to chronic and recurrent infections, ultimately increasing the healthcare burden. Consequently, preventing and eliminating biofilms has become a critical focus in clinical management and research. Aim of review: This review systematically examines the mechanisms underlying biofilm formation in S. aureus and its contribution to antibiotic resistance, emphasizing the essential roles biofilms play in maintaining structural integrity and enhancing resistance. It also analyses the protective mechanisms that fortify S. aureus biofilms against antimicrobial treatments. Furthermore, the review provides a comprehensive overview of recent therapeutic innovations, including enzymatic therapy, nanotechnology, gene editing, and phage therapy. Key scientific concepts of review: Emerging therapeutic strategies present novel approaches to combat S. aureus biofilm-associated infections through various mechanisms. This review discusses recent advancements in these therapies, their practical challenges in clinical application, and provides an in-depth analysis of each strategy’s mechanisms and therapeutic potential. By mapping future research directions, this review aims to refine anti-biofilm strategies to control infection progression and effectively mitigate recurrence.http://www.sciencedirect.com/science/article/pii/S2001037025000157Staphylococcus aureusBiofilmDrug resistanceInnovative therapeutic strategies |
| spellingShingle | Yanze Xia Zhenghui Hu Qiyuan Jin Qi Chen Chenhao Zhao Rui Qiang Zonggang Xie Liubing Li Haifang Zhang Structural characteristics, functions, and counteracting strategies of biofilms in Staphylococcus aureus Computational and Structural Biotechnology Journal Staphylococcus aureus Biofilm Drug resistance Innovative therapeutic strategies |
| title | Structural characteristics, functions, and counteracting strategies of biofilms in Staphylococcus aureus |
| title_full | Structural characteristics, functions, and counteracting strategies of biofilms in Staphylococcus aureus |
| title_fullStr | Structural characteristics, functions, and counteracting strategies of biofilms in Staphylococcus aureus |
| title_full_unstemmed | Structural characteristics, functions, and counteracting strategies of biofilms in Staphylococcus aureus |
| title_short | Structural characteristics, functions, and counteracting strategies of biofilms in Staphylococcus aureus |
| title_sort | structural characteristics functions and counteracting strategies of biofilms in staphylococcus aureus |
| topic | Staphylococcus aureus Biofilm Drug resistance Innovative therapeutic strategies |
| url | http://www.sciencedirect.com/science/article/pii/S2001037025000157 |
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