CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA

CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA

Co-transcriptional capping allows exogenous mRNAs to yield robust protein expression. Identifying additional mRNA modifications that further boost protein output will be crucial for developing more efficacious mRNA therapies. Using in vitro approaches, we found that the co-transcriptional cap analog...

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Bibliographic Details
Main Authors: Zachary F. Mandell, Andrew Ujita, Jordana Henderson, Anthony Truong, Coleen Vo, Farinaz Rezvani, Nona Abolhassani, Alexandre Lebedev, Chunping Xu, Inna Koukhareva, Stephanie Ramos, Kate Broderick, Benjamin Hudson, Jeff Coller
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
mRNA
mRNA medicines
mRNA therapeutics
mRNA durability
mRNA stability
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125000101
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