IL-22 signaling contributes to West Nile encephalitis pathogenesis.

IL-22 signaling contributes to West Nile encephalitis pathogenesis.

The Th17 cytokine, IL-22, regulates host immune responses to extracellular pathogens. Whether IL-22 plays a role in viral infection, however, is poorly understood. We report here that Il22(-/-) mice were more resistant to lethal West Nile virus (WNV) encephalitis, but had similar viral loads in the...

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Main Authors: Penghua Wang, Fengwei Bai, Lauren A Zenewicz, Jianfeng Dai, David Gate, Gong Cheng, Long Yang, Feng Qian, Xiaoling Yuan, Ruth R Montgomery, Richard A Flavell, Terrence Town, Erol Fikrig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044153&type=printable
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