In-silico analysis of potential phytochemicals targeting mitogen activating protein kinase-14 (MAPK14) gene in colorectal cancer

In-silico analysis of potential phytochemicals targeting mitogen activating protein kinase-14 (MAPK14) gene in colorectal cancer

Abstract A significant percentage of colorectal cancer (CRC) diagnoses are associated with overexpression of the MAPK14 gene MAPK14 gene or p38 MAPK. It is overexpressed in most cases of colorectal cancer (CRC) and is an important factor for tumor development. CRC is among the most common causes of...

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Main Authors: Meerab Khalid, Rana Muhammad Mateen, Mohsin Javed, Muhammad Ali, Mohammed Arif Nadeem Saqab, Rukhsana Parveen, Ahmed Asimov, Safura Bibi, Ali Bahadur, Shahid Iqbal, Sajid Mahmood, Salah Knani, Abeer Ahmed Alghamdi, Randa A. Althobiti, Lamiaa Galal Amin
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
In silico
MAPK14
CRC (CRC)
Fruquintinib
DFT
MD
Online Access:https://doi.org/10.1038/s41598-025-05807-2
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https://doi.org/10.1038/s41598-025-05807-2

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