S-adenosylmethionine metabolism shapes CD8+ T cell functions in colorectal cancer

S-adenosylmethionine metabolism shapes CD8+ T cell functions in colorectal cancer

Abstract Metabolite nutrients within the tumor microenvironment shape both tumor progression and immune cell functionality. It remains elusive how the metabolic interaction between T cells and tumor cells results in different anti-cancer immunotherapeutic responses. Here, we use untargeted metabolom...

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Bibliographic Details
Main Authors: Xiaohua Yang, Tianzhang Kou, Hongmiao Wang, Ji Zhu, Zheng-Jiang Zhu, Yuping Cai
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cancer & Metabolism
Subjects:
Metabolite nutrients
CD8+ T cell function
Microsatellite stable colorectal cancer
Metabolomics
S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) metabolism
Online Access:https://doi.org/10.1186/s40170-025-00394-2
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https://doi.org/10.1186/s40170-025-00394-2

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