CHST1 as a prognostic-related biomarker in gastric cancer correlating with immune infiltration
Carbohydrate sulfotransferase (CHST) is a Golgi membrane-associated enzyme with potential as a cancer diagnostic marker. In this study, we obtained the transcriptional profile and corresponding clinical information of CHST1 in gastric cancer (GC) tissues and normal tissues from The Cancer Genome Atl...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025005043 |
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| author | Long Gui Jin-hao Yu Jia-nan Tan Guang-yu Zhong Yong-xue Wang Lin Zhong Jiao-jiao Su Dong Hou Bin Yang Fang-hai Han Sheng-ning Zhou |
| author_facet | Long Gui Jin-hao Yu Jia-nan Tan Guang-yu Zhong Yong-xue Wang Lin Zhong Jiao-jiao Su Dong Hou Bin Yang Fang-hai Han Sheng-ning Zhou |
| author_sort | Long Gui |
| collection | DOAJ |
| description | Carbohydrate sulfotransferase (CHST) is a Golgi membrane-associated enzyme with potential as a cancer diagnostic marker. In this study, we obtained the transcriptional profile and corresponding clinical information of CHST1 in gastric cancer (GC) tissues and normal tissues from The Cancer Genome Atlas database. Our functional experiments have demonstrated that CHST1 enhances the proliferation and metastasis of GC cells, both in vitro and in vivo. Furthermore, we constructed a co-expression network of CHST1 and explored its relationship with clinicopathological features, the tumor microenvironment, and immune infiltration through bioinformatics analysis. Finally, relevant drugs that inhibit CHST1 in GC were predicted using the drug susceptibility database (CellMiner) and Cancer Immunome Atlas. Overall, CHST1 may serve as a promising prognostic biomarker for GC, as it is linked to immune infiltration and facilitates GC cell proliferation and metastasis. |
| format | Article |
| id | doaj-art-ea9d9d0afaea44d3a30cab3848d91ec8 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-ea9d9d0afaea44d3a30cab3848d91ec82025-01-30T05:14:35ZengElsevierHeliyon2405-84402025-02-01113e42124CHST1 as a prognostic-related biomarker in gastric cancer correlating with immune infiltrationLong Gui0Jin-hao Yu1Jia-nan Tan2Guang-yu Zhong3Yong-xue Wang4Lin Zhong5Jiao-jiao Su6Dong Hou7Bin Yang8Fang-hai Han9Sheng-ning Zhou10Department of Cardiothoracic Surgery, Lu 'an Hospital Affiliated to Anhui Medical University, Lu 'an, 237005, ChinaDepartment of Gastrointestinal Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, ChinaDepartment of Gastrointestinal Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, ChinaDepartment of Gastrointestinal Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, ChinaDepartment of Pediatrics, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, ChinaDepartment of Gastrointestinal Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, ChinaDepartment of Gastroenterology, Lu 'an Hospital Affiliated to Anhui Medical University, Lu 'an, 237005, ChinaDepartment of Gastrointestinal Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, ChinaDepartment of Gastrointestinal Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China; Corresponding author.Department of Gastrointestinal Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China; Corresponding author.Department of Gastrointestinal Surgery, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China; Corresponding author.Carbohydrate sulfotransferase (CHST) is a Golgi membrane-associated enzyme with potential as a cancer diagnostic marker. In this study, we obtained the transcriptional profile and corresponding clinical information of CHST1 in gastric cancer (GC) tissues and normal tissues from The Cancer Genome Atlas database. Our functional experiments have demonstrated that CHST1 enhances the proliferation and metastasis of GC cells, both in vitro and in vivo. Furthermore, we constructed a co-expression network of CHST1 and explored its relationship with clinicopathological features, the tumor microenvironment, and immune infiltration through bioinformatics analysis. Finally, relevant drugs that inhibit CHST1 in GC were predicted using the drug susceptibility database (CellMiner) and Cancer Immunome Atlas. Overall, CHST1 may serve as a promising prognostic biomarker for GC, as it is linked to immune infiltration and facilitates GC cell proliferation and metastasis.http://www.sciencedirect.com/science/article/pii/S2405844025005043Gastric cancerCHST1BiomarkerPrognosisImmune infiltration |
| spellingShingle | Long Gui Jin-hao Yu Jia-nan Tan Guang-yu Zhong Yong-xue Wang Lin Zhong Jiao-jiao Su Dong Hou Bin Yang Fang-hai Han Sheng-ning Zhou CHST1 as a prognostic-related biomarker in gastric cancer correlating with immune infiltration Heliyon Gastric cancer CHST1 Biomarker Prognosis Immune infiltration |
| title | CHST1 as a prognostic-related biomarker in gastric cancer correlating with immune infiltration |
| title_full | CHST1 as a prognostic-related biomarker in gastric cancer correlating with immune infiltration |
| title_fullStr | CHST1 as a prognostic-related biomarker in gastric cancer correlating with immune infiltration |
| title_full_unstemmed | CHST1 as a prognostic-related biomarker in gastric cancer correlating with immune infiltration |
| title_short | CHST1 as a prognostic-related biomarker in gastric cancer correlating with immune infiltration |
| title_sort | chst1 as a prognostic related biomarker in gastric cancer correlating with immune infiltration |
| topic | Gastric cancer CHST1 Biomarker Prognosis Immune infiltration |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025005043 |
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